This trial is studying whether adding ibrutinib to chemotherapy before and after stem cell transplant helps the transplant work better in patients with relapsed or refractory diffuse large B-cell lymphoma.
- Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type
- Diffuse Large B-Cell Lymphoma Activated B-Cell Type (DLBCL-ABC)
1 Primary · 7 Secondary · Reporting Duration: The time between randomization and death from any cause, assessed up to 5 years (60 months)
Side Effects for
Awards & Highlights
2 Treatment Groups
Arm I (ibrutinib, chemotherapy, autoHCT)
1 of 2
Arm II (placebo, chemotherapy, autoHCT)
1 of 2
302 Total Participants · 2 Treatment Groups
Primary Treatment: Autologous Hematopoietic Stem Cell Transplantation · Has Placebo Group · Phase 3
Who is running the clinical trial?
Age 18+ · All Participants · 0 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
What is the FDA's opinion on Autologous Hematopoietic Stem Cell Transplantation?
"Autologous Hematopoietic Stem Cell Transplantation is considered safe, as it has received a score of 3." - Anonymous Online Contributor
What are some precedents for this type of blood-based stem cell therapy?
"City of Hope Comprehensive Cancer Center first studied Autologous Hematopoietic Stem Cell Transplantation in 1997. So far, 2255 clinical trials have completed with 1331 still active. Many of these studies are based out of Clackamas, Oregon." - Anonymous Online Contributor
Are there any current vacancies in this trial for new participants?
"That is correct, the online clinical database has this study listed as 'seeking participants'. The trial was created on 7/6/2016 and updated for the last time on 11/11/2022. They are looking for 302 individuals from 100 different locations to take part in the study." - Anonymous Online Contributor
How many people are being given the opportunity to participate in this clinical trial?
"That is correct. The trial, which was originally posted on July 6th 2016 and updated November 11th 2020, is still recruiting patients at 100 sites across the United States of America. They are looking for a total of 302 participants." - Anonymous Online Contributor
What are the most frequent diagnoses that Autologous Hematopoietic Stem Cell Transplantation is used to treat?
"Autologous Hematopoietic Stem Cell Transplantation is a standard treatment for various lung cancers, as well as other diseases such as small cell lung cancer (sclc), multiple sclerosis, leukemia, myelocytic, and acute." - Anonymous Online Contributor
In how many different settings is this experiment being conducted today?
"There are 100 medical centres enrolling patients for this trial, with locations in Clackamas, Hazleton and Norton Shores. If you wish to minimize travel time and distance, please select the nearest site to your location." - Anonymous Online Contributor