This trial is evaluating whether Renal Autologous Cell Therapy (REACT) will improve 2 primary outcomes and 25 secondary outcomes in patients with Type 2 Diabetes Mellitus. Measurement will happen over the course of From baseline thru week 34.
This trial requires 50 total participants across 5 different treatment groups
This trial involves 5 different treatments. Renal Autologous Cell Therapy (REACT) is the primary treatment being studied. Participants will be divided into 5 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"Approximately 8 in 10 persons ≥ 40 years old and 1 in 5 persons ≥ 60 years old have some degree of albuminuria compared to the general US population." - Anonymous Online Contributor
"The causes of kidney diseases include genetic and environmental risk factors such as family history, lifestyle and environmental factors, and drug use. There are no single factors that explain why the disease process happens. It remains an exciting field for research in the 21st century." - Anonymous Online Contributor
"Kidney diseases can seldom be cured. All treatments aim at relieving symptoms rather than curing diseases. But it is possible that some of the treatments listed are effective in the treatment of renal diseases, especially glucosuria and hyperkalemia." - Anonymous Online Contributor
"There exists a wide range of kidney diseases that can be categorised into nine major and several minor group diseases. Their presence, severity and distribution varies widely from person to person and with age and sex." - Anonymous Online Contributor
"There are a variety of reasons that children may have renal disease. Some of the first signs are vomiting and/or a decrease in growth. Other common signs are pain and a decreased amount of urine output. Renal disease also may result from the child's body not functioning properly. These include problems metabolizing proteins and blood proteins, as well as electrolytes like sodium and potassium. Renal disease can also cause damage to the kidneys, often resulting in shortness of breath. While the signs of kidney disease are similar in children, one must have an eye on the possibility of any rash or itching to check for signs of an autoimmune reaction." - Anonymous Online Contributor
"Kidney disease is often treated with drugs that act on the renal tubules and glomeruli to reduce proteinuria and blood pressure. A range of non-pharmaceutical interventions are available to manage renal disease." - Anonymous Online Contributor
"There have been many new methods of treating kidney diseases, but with limited success. Many drugs are in clinical trials or trials in general, and their efficacy should be evaluated by a physician specializing in kidney disease." - Anonymous Online Contributor
"Most investigators are interested in more comprehensive knowledge of kidney diseases, and the best knowledge to support an effective prevention. New discoveries in the fields include those that clarify the effects of diet and lifestyle factors and the mechanisms influencing inflammation. It is imperative that clinicians integrate the results into a conceptual framework to better counsel patients and their patients' families about the optimal management of the disease." - Anonymous Online Contributor
"Despite a relatively small number of studies and trials, the authors identified multiple treatments of renal AC cell therapy, but most of these trials were performed alongside other cell therapies or medication. The authors concluded that more research is needed before further consideration for use in clinical practice can be made." - Anonymous Online Contributor
"Renal autologous cell therapy at doses of up to 1 x 106/kg was well tolerated even in elderly persons with advanced renal disease. Treatment did not cause a significant increase in serum creatinine or creatinine clearance. Results from a recent paper indicate that autologous cells administered for chronic kidney maintenance therapy, even in individuals>75 years, can be safely and effectively delivered to this patient population." - Anonymous Online Contributor
"These data warrant further studies to see whether the new therapeutic approaches incorporating react cell transfusions will prove efficacious in the treatment of chronic diseases of the kidneys and if possible in other disease states, such as diabetes mellitus." - Anonymous Online Contributor
"Age when getting kidney diseases is generally higher with patients that have more comorbid illnesses and that have been receiving medical care for a longer period of time. The average age of kidney diseases at the age of first diagnosis is around 49.5 years among all the races and around 49 years among whites." - Anonymous Online Contributor