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Proton Therapy for Recurrent Head and Neck Cancer

Phase 2
Waitlist Available
Led By Nancy Lee, MD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age ≥18 years at the time of consent
A history of prior radiation to the head and neck (≥ 40 Gy, in 2 Gy/fraction equivalent)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

Study Summary

This trial tests proton therapy as a cancer treatment for head and neck cancer patients whose cancer has returned. They will measure tumor control and side effects.

Who is the study for?
This trial is for adults over 18 with recurrent or new primary head and neck cancer, previously treated with radiation. It's not suitable for pregnant women, those unable to follow the study procedures, or patients who finished prior radiation less than 6 months ago.Check my eligibility
What is being tested?
The study tests proton therapy as a treatment for recurring head and neck cancer. Patients will receive either full dose re-irradiation if they have more than 6 months life expectancy or palliative care if less.See study design
What are the potential side effects?
Potential side effects of proton therapy may include skin reactions, fatigue, dry mouth, difficulty swallowing, and changes in taste. The severity can vary based on individual patient factors.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I have received radiation treatment to my head or neck area.
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My cancer in the head or neck area has come back or is a new one.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
locoregional recurrence-free

Trial Design

2Treatment groups
Experimental Treatment
Group I: hypofractionated palliative re-irradiationExperimental Treatment1 Intervention
Group II: fractionated full dose re-irradiationExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,934 Previous Clinical Trials
588,717 Total Patients Enrolled
Nancy Lee, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
12 Previous Clinical Trials
2,011 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many healthcare facilities are presently conducting this experiment?

"This study is currently open to participants at 9 centres, two of which are located in Harrison and Miami. There are other locations available that may be closer to you; we recommend selecting the closest location for your convenience."

Answered by AI

Are there still slots available for participants in this clinical trial?

"Affirmative. According to information on clinicaltrials.gov, this investigation is actively recruiting participants and was first listed on July 10th 2017. As of October 21st 2022, 88 patients are required for the trial at 9 distinct sites."

Answered by AI

How many individuals are enrolled in this experiment?

"To initiate this clinical trial, 88 eligible patients must enroll. Memorial Sloan Kettering Westchester in Harrison, New york and the Cancer Center in Florida are two of many locations offering participation opportunities."

Answered by AI

To what extent can hypofractionated palliative re-irradiation pose a hazard to patients?

"There is some existing clinical evidence which suggests hypofractionated palliative re-irradiation's safety, so it has been given a rating of 2."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Proton Re-Irradiation for Recurrent Head and Neck Cancer
2017. "Proton Re-Irradiation for Recurrent Head and Neck Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03217188.
~13 spots leftby Jul 2025
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