Proton Therapy for Recurrent Head and Neck Cancer
Trial Summary
Do I need to stop my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of this treatment for recurrent head and neck cancer?
Research suggests that intensity-modulated proton therapy (IMPT) can reduce damage to nearby healthy organs compared to traditional radiation methods, potentially leading to fewer side effects like reduced feeding tube dependency. This is due to the precise targeting ability of proton therapy, which is particularly beneficial for head and neck cancers.12345
Is proton therapy safe for treating head and neck cancer?
Proton therapy, including intensity-modulated proton therapy (IMPT), has been shown to reduce the exposure of healthy organs to radiation compared to traditional methods, which can lead to fewer side effects like reduced feeding tube dependency. While more studies are needed, initial experiences suggest it is generally safe for treating head and neck cancers.13456
How is proton therapy different from other treatments for recurrent head and neck cancer?
Proton therapy, specifically intensity-modulated proton therapy (IMPT), is unique because it precisely targets tumors while minimizing damage to surrounding healthy tissues, which can reduce side effects compared to traditional radiation therapies. This is particularly beneficial for head and neck cancers, where critical structures are closely located, and it may lead to better quality of life by reducing complications like pain and difficulty swallowing.12378
What is the purpose of this trial?
The purpose of this study is to evaluate the tumor control and the side effects of using proton therapy for head and neck cancer that has come back.
Research Team
Nancy Lee, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Eligibility Criteria
This trial is for adults over 18 with recurrent or new primary head and neck cancer, previously treated with radiation. It's not suitable for pregnant women, those unable to follow the study procedures, or patients who finished prior radiation less than 6 months ago.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive proton therapy for recurrent head and neck cancer
Follow-up
Participants are monitored for locoregional recurrence and side effects after treatment
Treatment Details
Interventions
- Conventionally Fractionated Full Dose Re-irradiation
- Hypofractionated Palliative Re-irradiation
- Proton Therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor