Translaryngeal Vibration for Hoarseness
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new method for treating muscle tension dysphonia (MTD), a voice disorder that causes a hoarse or strained voice. The study examines whether throat vibrations can improve the voice more effectively than regular therapy without vibrations. Participants will receive either five or eight weeks of voice therapy with vibration or eight weeks of therapy with a placebo vibration. Individuals diagnosed with MTD by a doctor who have not previously tried vibration therapy may be suitable for this trial. As a Phase 3 trial, this treatment represents the final step before FDA approval, offering participants the opportunity to contribute to a potentially groundbreaking therapy.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that voice therapy using vibration is generally easy for people to handle. In one study, participants experienced significant improvements in their voice without any serious side effects. Another study found that this therapy can improve voice quality and reduce strain. Since this treatment is in the final stages of testing, earlier tests likely did not find major safety concerns. Overall, the evidence indicates that vibration-based voice therapy is a safe option for people with voice disorders.12345
Why do researchers think this study treatment might be promising for hoarseness?
Researchers are excited about the translaryngeal vibration technique for hoarseness because it introduces a unique approach by using vibration during voice therapy. Unlike standard treatments such as vocal rest, medications, or traditional voice therapy, this method potentially enhances vocal recovery by directly stimulating the vocal cords. The trial examines two durations of therapy—five weeks and eight weeks—alongside a placebo group, which could help determine the optimal treatment length. This innovative use of vibration aims to improve vocal function more effectively and possibly more quickly than existing options.
What evidence suggests that translaryngeal vibration is effective for muscle tension dysphonia?
Research has shown that vibration therapy might be a promising way to treat voice problems like muscle tension dysphonia (MTD). In one study, up to 57% of participants noticed significant improvement in voice quality after using vibration therapy on their voice box. Other studies have found that this therapy also improved how people felt about their voice and reduced the impact of voice problems on their lives. This trial will compare different durations of voice therapy with vibration, including five-week and eight-week therapies, as well as a placebo version. Overall, early results are encouraging and suggest that vibration therapy could effectively treat hoarseness and other voice issues.16789
Are You a Good Fit for This Trial?
This trial is for individuals with voice disorders like dysphonia or hoarseness, specifically those experiencing muscle tension in their vocal cords. Participants should be diagnosed with a hyperfunctional voice disorder and have not found relief from standard treatments.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive voice therapy with translaryngeal vibration or placebo for 5 or 8 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Voice therapy with vibration
Find a Clinic Near You
Who Is Running the Clinical Trial?
Texas Christian University
Lead Sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator