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Proton Beam Therapy

MRIdian Radiation Treatment Unit for Breast Cancer (MAPBI Trial)

Phase 2

Waitlist Available

Led By Bethany Anderson, MD

Research Sponsored by University of Wisconsin, Madison

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

MAPBI Trial Summary

This trial will investigate a novel 3-fraction radiation regimen for participants undergoing breast-conserving therapy (BCT) for early breast cancer. The hypothesis is that 3-fraction radiation therapy can be delivered safely without compromising the therapeutic ratio. Participants can expect to be on study for follow up up to 5 years.

Eligible Conditions

Breast Cancer
Ductal Carcinoma
Lobular Carcinoma in Situ

MAPBI Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Physician Reported Cosmesis: 1-year

Secondary outcome measures

Acute Radiation Toxicity

Disease Free Survival (DFS)

Ipsilateral Breast Tumor Recurrence (IBTR)

+8 more

MAPBI Trial Design

1Treatment groups

Experimental Treatment

Group I: 8.2 Gy Radiation TherapyExperimental Treatment1 Intervention

Accelerated partial breast irradiation using 3 x 8.2 Gy to the lumpectomy cavity with a 3mm PTV margin. Treatment duration will be 5-6 days and treatments will be on alternative weekdays, with a minimum interval of 40 hours between subsequent fractions.

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Find a Location

Who is running the clinical trial?

University of Wisconsin, MadisonLead Sponsor

1,184 Previous Clinical Trials

3,169,541 Total Patients Enrolled

35 Trials studying Breast Cancer

38,489 Patients Enrolled for Breast Cancer

Bethany Anderson, MDPrincipal InvestigatorUniversity of Wisconsin, Madison

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are we recruiting test subjects for this research project at the moment?

"The study, which has been active since 5/16/2022 according to clinicaltrials.gov, is looking for participants."

Answered by AI

What is the safety record of MRIdian Radiation Treatment Unit for patients?

"Given that this is a Phase 2 trial - meaning there is some clinical data supporting safety but not efficacy - Power rates the MRIdian Radiation Treatment Unit as a 2."

Answered by AI

How many people are allowed to join this clinical trial?

"Yes, according to the latest update on clinicaltrials.gov, this study is still looking for more patients. This particular trial was posted on May 16th, 2022 and updated May 17th, 2022. They are hoping to enroll 30 individuals at a single location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer

2022. "Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03936478.