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PRDR WBRT for Brain Cancer
Study Summary
This trial is testing a new way to give radiation therapy to the brain. Patients will get radiation therapy every day for 10 days.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have had whole brain radiation therapy before.I have had treatment that affects my whole body.I was 18 or older when my brain cancer was diagnosed.I will start whole brain radiation therapy within two weeks after signing up.I am a native English speaker.I have a history of dementia not related to my brain cancer.I have brain metastasis that can be measured.My cancer has spread to the lining of my brain and spinal cord.I cannot take memantine or similar medications due to health reasons.I had treatment for brain metastasis and completed it at least a week ago for SRS or two weeks ago for surgery.My cancer has spread from the blood or brain.My cancer treatment is aimed at curing the disease.My tumor is larger than 5 cm and has not been removed.My kidney function is severely reduced or I am on dialysis.I had an open biopsy more than a week ago, or I had a stereotactic biopsy.I can do most of my daily activities without help.I have cancer that has spread to my brain, confirmed by a biopsy.I have had cancer before, but it's under control and not affecting my daily activities or life expectancy.
- Group 1: WBRT-PRDR plus memantine.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many participants are currently enrolled in the research study?
"That is accurate. According to the details posted on clinicaltrials.gov, this research project first appeared on November 17th 2021 and was recently adjusted as of April 5th 2022. The goal is to enlist 53 patients from a single medical location."
Could you please elucidate the risks posed by WBRT under PRDR procedures?
"Taking all possible factors into consideration, the safety rating of WBRT with PRDR is approximated at a 2. This assessment takes into account that this is only Phase 2 trial and there has yet to be data demonstrating efficacy."
Is enrollment open for this investigation?
"Indeed. On clinicaltrials.gov, this trial is listed as actively recruiting participants since its inception on November 17th 2021 and last edit on April 5th 2022. The study seeks to enroll 53 patients from a single medical centre."
Has there been an exploration of whole brain radiation therapy (WBRT) with the utilization of planar radiotherapy dose reduction (PRDR) in any other studies?
"Currently, 25 trials are in progress researching WBRT and its potential efficacy when using the PRDR technique. Of those studies, 11 have now advanced to Phase 3 of clinical trial research. While many West Bend, Wisconsin-based sites are running these experiments, there is a total of 294 locations conducting this inquiry worldwide."
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