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N/A

Overnight Fasting for Health Improvement in Childhood Cancer Survivors

N/A
Recruiting
Led By Danielle Friedman, MD, MS
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Current age ≥18 years
History of treatment for cancer or related illness diagnosed at ≤ 25 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial is testing whether fasting for at least 14 hours overnight can help improve blood sugar levels.

Who is the study for?
Adults over 18 who survived childhood cancer, speak English, can text, and have a personal phone. They must be off cancer treatments for at least 2 years and willing to wear a FitBit-like device. Not eligible if they already fast for 12+ hours, are pregnant, or take certain medications affecting diet or blood sugar.Check my eligibility
What is being tested?
The OnFACT Study is testing if not eating for at least 14 hours overnight (intermittent fasting) is doable and beneficial for regulating blood sugar in adults who had cancer as children.See study design
What are the potential side effects?
This trial may not have direct side effects from medication but could include hunger pangs, changes in energy levels during fasting periods, potential impact on sleep patterns, and possible alterations in mood or concentration.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I was treated for cancer or a related illness before I turned 26.
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I am not undergoing chemotherapy or radiation therapy currently.
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I have had radiation therapy to my chest, abdomen, or whole body.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Participation completion
Secondary outcome measures
measure of glucose metabolism

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: prolonged overnight fastingExperimental Treatment1 Intervention
Participants randomized to the fasting arm will be instructed on how to use the SMS texting app to indicate the beginning and end of the nightly fast. In the first 2-4 weeks following the first overnight fast, intervention participants will complete three phone calls with study staff trained in motivational interviewing. These calls will be used to reinforce the prolonged overnight fasting instructions, identify barriers to prolonged overnight fasting, and support successes where they have occurred.
Group II: usual careActive Control1 Intervention
Participants randomized to the usual care arm will be instructed to eat a heart-healthy diet and exercise for at least 30 minutes five days a week, which is usual counseling in our clinics.

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,936 Previous Clinical Trials
588,858 Total Patients Enrolled
Rockefeller UniversityOTHER
158 Previous Clinical Trials
16,317 Total Patients Enrolled
Danielle Friedman, MD, MSPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
1 Previous Clinical Trials
1,068 Total Patients Enrolled

Media Library

Prolonged Overnight Fasting (N/A) Clinical Trial Eligibility Overview. Trial Name: NCT03523377 — N/A
Childhood Cancer Survivors Research Study Groups: prolonged overnight fasting, usual care
Childhood Cancer Survivors Clinical Trial 2023: Prolonged Overnight Fasting Highlights & Side Effects. Trial Name: NCT03523377 — N/A
Prolonged Overnight Fasting (N/A) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03523377 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people are currently enrolled in this trial?

"Yes, the information on clinicaltrials.gov says that this clinical trial is currently recruiting patients. The trial was initially posted on 4/27/2018 and was most recently edited on 10/19/2022. The clinical trial is enrolling 40 patients across 1 sites"

Answered by AI

Are investigators still looking for participants for this trial?

"The listing on clinicaltrials.gov verifies that this study is still open to enrolling patients. The trial was first posted on April 27th, 2018 and has been updated as recently as October 19th, 2020. Currently, the research is being conducted with 40 participants at a single site."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Overnight Fasting After Completion of Therapy: The OnFACT Study
2018. "Overnight Fasting After Completion of Therapy: The OnFACT Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03523377.
~10 spots leftby Apr 2026
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