Diet Composition for Healthy Eating

(MUTT Trial)

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: David Baer

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

Duration: 5 months

128 Participants Needed

Trial Summary

What is the purpose of this trial?

Overconsumption of carbohydrates has been implicated as a cause of significant public health problems including obesity and diabetes. The most effective approach to alter dietary pattern and improve public health is unknown. Gradual and abrupt changes in dietary pattern have been tried in small, uncontrolled trials, but it is not clear which approach is most effective. The primary objective of this study is to evaluate different approaches to changing dietary pattern for altering flavor perception in foods and beverages and for altering preference for flavor.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it excludes those who have used medications affecting taste within one month prior to the study.

What data supports the effectiveness of the treatment Diet composition 1, Diet composition 2, Diet composition 3, Diet composition 4?

The research suggests that individualized dietary counseling, when combined with specific dietary interventions like a protein-enriched menu, can improve nutritional intake in patients, indicating that tailored diet compositions may be effective in promoting better health outcomes. ^{1 2 3 4 5}

Is the diet composition treatment generally safe for humans?

There is no specific safety data available for the diet composition treatment under the names Diet composition 1, 2, 3, or 4. However, general safety concerns exist for dietary supplements, as adverse events have been reported, often due to inappropriate use or interactions with other foods or drugs. ^{6 7 8 9 10}

How does the treatment 'Diet Composition for Healthy Eating' differ from other treatments for promoting health?

The 'Diet Composition for Healthy Eating' treatment is unique because it focuses on different diet compositions to promote health and reduce the risk of chronic diseases, unlike standard treatments that may not emphasize dietary changes. This approach is similar to the Mediterranean diet, which is known for its health benefits and cultural significance. ^{11 12 13 14 15}

Research Team

Paul Wise, PhD

Principal Investigator

Monell Chemical Senses Center

Eligibility Criteria

This study is for individuals interested in healthy eating. The trial aims to include participants who are willing to try different diets that change their usual intake of carbohydrates. Specific eligibility criteria were not provided, so it's best to contact the researchers for details on who can join.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

1 visit (in-person)

Baseline

Participants undergo baseline measurements and assessments

1 month

Weekly visits (in-person)

Treatment

Participants follow a specified diet with different macronutrient compositions

5 months

Monthly visits (in-person)

Follow-up

Participants are monitored for changes in taste perception and food preference

1 month

1 visit (in-person)

Treatment Details

Interventions

• Diet composition 1
• Diet composition 2
• Diet composition 3
• Diet composition 4

Trial Overview The Monell USDA Taste Test Study is testing three different diet compositions to see how they affect taste perception and preference for flavors in foods and beverages. It explores whether gradual or abrupt changes in diet are more effective at improving dietary patterns.

Participant Groups

Group I: Diet composition 3 Experimental Treatment 1 Intervention

A diet with a specified macronutrient composition different from arms 1 and 2, based on the current information about the US macronutrient composition.

Group II: Diet composition 2 Experimental Treatment 1 Intervention

A diet with a specified macronutrient composition different from arms 1 and 3.

Group III: Diet composition 1 Experimental Treatment 1 Intervention

A diet with a specified macronutrient composition different from arms 2 and 3.

Who Is Running the Clinical Trial?

David Baer

Lead Sponsor

Trials

2

Recruited

150+

National Institute on Deafness and Other Communication Disorders (NIDCD)

Collaborator

Trials

377

Recruited

190,000+

Monell Chemical Senses Center

Collaborator

Trials

22

Recruited

2,200+

Findings from Research

In a study of hospitalized patients at nutrition risk, combining a protein-enriched menu with individualized dietary counseling led to 92% of patients meeting over 75% of their energy requirements, compared to 76% in the historical intervention group.

The intervention group also showed a significant increase in mean energy and protein intake, with 31 kcal/kg and 1.2 g protein/kg, respectively, indicating that this combined approach is more effective than using a protein-enriched menu alone.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

From Evidence to Clinical Practice: Positive Effect of Implementing a Protein-Enriched Hospital Menu in Conjunction With Individualized Dietary Counseling. Munk, T., Bruun, N., Nielsen, MA., et al.[2018]

The increasing use of health foods for disease prevention has raised concerns about potential risks, as many consumers are unaware of the adverse effects that can arise from inappropriate use, such as combining multiple health foods or mixing them with medications.

To address these safety concerns, the Health Foods Network (HFNet) was created as an online database to provide healthcare professionals with evidence-based information on the safety and effectiveness of health foods, aiming to improve patient consultations and promote safe usage.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

[Information System on the Safety and Effectiveness of Health Foods and Recent Topics]. Chiba, T.[2019]

References

1. Belgium pubmed.ncbi.nlm.nih.gov

Computer-assisted production of dietary advice: a useful tool for the future? [2015]

2. United States pubmed.ncbi.nlm.nih.gov

Comparing nutritional requirements, provision and intakes among patients prescribed therapeutic diets in hospital: An observational study. [2018]

3. United States pubmed.ncbi.nlm.nih.gov

Diet needs of patients referred to home health. [2004]

4. England pubmed.ncbi.nlm.nih.gov

Special diets in hospitals: discrepancy between what is prescribed and what is eaten. [2019]

5. United States pubmed.ncbi.nlm.nih.gov

From Evidence to Clinical Practice: Positive Effect of Implementing a Protein-Enriched Hospital Menu in Conjunction With Individualized Dietary Counseling. [2018]

6. United States pubmed.ncbi.nlm.nih.gov

Development of food tables and use with computers. Review of nutrient data bases. [2000]

7. Netherlands pubmed.ncbi.nlm.nih.gov

Collection of occurrence data in foods - The value of the BfR MEAL study in addition to the national monitoring for dietary exposure assessment. [2022]

8. United States pubmed.ncbi.nlm.nih.gov

Future directions in food composition studies. [2018]

9. United States pubmed.ncbi.nlm.nih.gov

Dietary supplement adverse events: report of a one-year poison center surveillance project. [2021]

10. Japan pubmed.ncbi.nlm.nih.gov

[Information System on the Safety and Effectiveness of Health Foods and Recent Topics]. [2019]

11. Spain pubmed.ncbi.nlm.nih.gov

[The scientific basis for healthy eating]. [2009]

12. United States pubmed.ncbi.nlm.nih.gov

Nutrition and health communication: the message and the media over half a century. [2019]

13. England pubmed.ncbi.nlm.nih.gov

Nutrition and the life cycle 4: the healthy diet for the adult. [2005]

14. United States pubmed.ncbi.nlm.nih.gov

Obesity treatment: can diet composition play a role? [2019]

15. United States pubmed.ncbi.nlm.nih.gov

The Association of Dietary Quality Indices and Cancer Mortality: A Systematic Review and Meta-analysis of Cohort Studies. [2019]