Enhanced PET Scan Techniques for Disease Imaging

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Michael V Knopp, MD, PhD profile photo
Overseen ByMichael V Knopp, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Cincinnati
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores new methods to enhance PET scans, which are imaging tests that help doctors see inside the body. The aim is to improve scan processing and compare new techniques with standard ones used in healthcare. The trial consists of two parts: one for individuals currently receiving a standard PET scan and another for those who have had one in the past. Individuals who are receiving or have received a standard PET scan at OSU might be suitable for this trial. As an unphased study, this trial offers participants the opportunity to contribute to advancements in medical imaging technology.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to ask the trial coordinators for more details.

What prior data suggests that these PET scan techniques are safe?

Research has shown that Positron Emission Tomography (PET) is generally safe for people. The main safety concern involves the special substances, called tracers, used in the scans. These tracers are usually well-tolerated at the doses used for imaging tests.

The FDA considers experimental PET drugs reasonably safe when used at the recommended dose. Additionally, articles about PET and CT (computed tomography) scans often emphasize safety for both patients and the staff operating the equipment, further supporting the idea that PET imaging is generally safe.

While this information is reassuring, prospective participants should ask questions and seek more details from the study team before joining any clinical trial.12345

Why are researchers excited about this trial?

Researchers are excited about the Enhanced PET Scan Techniques because they aim to revolutionize disease imaging by providing clearer and more detailed images. Unlike traditional imaging methods, this advanced PET scan could potentially detect diseases earlier and with more precision, leading to better patient outcomes. The technique promises to improve diagnostic accuracy by enhancing the visibility of abnormalities at a molecular level. This could mean faster diagnoses and the ability to tailor treatments more effectively to individual patients.

What evidence suggests that these enhanced PET scan techniques are effective for disease imaging?

Research has shown that PET scans serve as a powerful tool for diagnosing and understanding various diseases, such as cancer and heart disease. Studies have found that PET scans accurately identify tumor stages in 86% of cases, outperforming other methods. They also help detect infections and inflammation, aiding doctors in making precise diagnoses and treatment plans. This trial will explore enhanced PET scan techniques, with participants in both prospective and retrospective populations undergoing these advanced imaging methods. This advanced imaging allows doctors to see how organs and tissues function inside the body, providing crucial information for treatment decisions. Overall, PET scans effectively detect and evaluate many medical conditions.678910

Who Is on the Research Team?

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Michael V Knopp, MD, PhD

Principal Investigator

Ohio State University

Are You a Good Fit for This Trial?

This trial is for men and women aged 18 or older who are already scheduled to receive a standard PET scan at OSU. It's designed to refine PET imaging techniques and compare them with current methods.

Inclusion Criteria

Patients who have previously received a standard of care PET scan at OSU
Patients receiving a standard of care PET scan at OSU

Exclusion Criteria

Participants who are pregnant or lactating
Prisoners
I am unable to understand or sign the consent form.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Prospective Imaging

Participants undergo investigational PET acquisitions in addition to standard of care PET imaging to develop and optimize PET acquisition post-processing techniques.

Up to 2 hours per session
1 visit (in-person)

Retrospective Data Review

Review of pre-existing PET imaging data collected from January 1, 2001, through December 5, 2017, for comparison with investigational images.

Ongoing throughout study

Follow-up

Participants are monitored for safety and effectiveness after imaging procedures

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Investigational Positron Emission Tomography
Trial Overview The study is testing new ways of processing images from PET scans, which could improve how we visualize what's happening inside the body. Participants will have their standard care PET images compared with these new investigational procedures.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Retrospective populationExperimental Treatment1 Intervention
Group II: Prospective populationExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Cincinnati

Lead Sponsor

Trials
442
Recruited
639,000+

Ohio State University

Lead Sponsor

Trials
891
Recruited
2,659,000+

Citations

Positron Emission Tomography (PET) in Oncology - PMCNevertheless, FDG-PET/CT turned out the most accurate tool for T staging assessment, with a correct T staging definition in 86% of patients, as compared to 68% ...
Positron Emission Tomography Scan Clinical TrialsThe aims of this research project are to assess the effectiveness of motion correction software for patients undergoing PET brain scans, to assess the data ...
LCD - Positron Emission Tomography (PET) Scan for ...Final diagnosis was achieved as follows: infectious disease 36.5% (111/303), malignancies 18.4% (56/303), and non-infectious inflammatory conditions 17.1% (52/ ...
Positron emission tomography scanWhy it's done. A PET scan is an effective way to help discover a variety of conditions, including cancer, heart disease and brain disorders.
Positron Emission Tomography (PET) - Medical Clinical ...Overview of the clinical effectiveness of positron emission tomography imaging in selected cancers. Health Technol Assess. 2007;11(44):1-304. Facey K ...
Investigational-New-Drug-Applications-for-Positron- ...FDA anticipates that most investigational uses of PET drugs will be conducted under an IND ... Investigational PET Drug Is Reasonably Safe at the Dose and ...
Radiation Safety With Positron Emission Tomography and ...This article addresses the radiation safety issues posed by PET/CT with regard to the protection and safety of PET/CT personnel, the public, and adult and ...
NCA - Positron Emission Tomography (FDG) (CAG-00065N)The safety of PET is usually discussed in terms of the safety of the positron emitting radiopharmaceuticals or tracers.
Study Details | NCT07110519 | Positron Emission ...... Positron Emission Tomography (PET) scans. The primary objective of this study is to generate safety data in healthy adult human volunteers. In the future ...
The Promise and Pitfalls of Positron Emission Tomography ...The CT scan from the PET/CT produces a data source for an attenuation map. PET images quite accurately provide quantitative radioactivity measurements in vivo.
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