26 Participants NeededMy employer runs this trial

Elranatamab + Cyclophosphamide for Multiple Myeloma

Recruiting at 6 trial locations
AL
CR
Overseen ByCarlyn Rose Tan, MD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to find out whether the combination of elranatamab and cyclophosphamide is an effective treatment for people with relapsed/refractory multiple myeloma (MM) who have risk factors that may affect how well their disease would respond to elranatamab alone.

Who Is on the Research Team?

AL

Alexander Lesokhin, MD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Are You a Good Fit for This Trial?

Inclusion Criteria

I have been diagnosed with multiple myeloma by a doctor.
* Serum M-protein ≥0.5 g/dL by SPEP
* Serum immunoglobulin free light chain ≥10 mg/dL (≥100 mg/L) AND abnormal serum immunoglobulin kappa to lambda free light chain ratio (\<0.26 or \>1.65)
See 7 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive a combination of elranatamab and cyclophosphamide

6 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Cyclophosphamide
  • Elranatamab

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Participants with Multiple MyelomaExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials
1,998
Recruited
602,000+

Pfizer

Industry Sponsor

Trials
4,712
Recruited
50,980,000+
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Vaccine Innovations
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Albert Bourla

Pfizer

Chief Executive Officer since 2019

PhD in Biotechnology of Reproduction, Aristotle University of Thessaloniki

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Patrizia Cavazzoni

Pfizer

Chief Medical Officer

MD from McGill University