Phenylephrine for Mitral Valve Regurgitation
Trial Summary
What is the purpose of this trial?
The study proposes to develop a phenylephrine protocol to be used during transesophageal echocardiography, whereby intravenous phenylephrine would be used to increase afterload with the intent to mimic the awake hemodynamic profile and variation that occurs with normal physical activity. The expectation is to see changes in severity of Mitral Regurgitation (MR) grade with increasing afterload, which in turn can provide more accurate quantification of MR severity to assist in clinical decision making.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the drug Phenylephrine for Mitral Valve Regurgitation?
The research does not provide direct evidence for the effectiveness of Phenylephrine in treating Mitral Valve Regurgitation. However, one case report mentions the use of Phenylephrine to maintain stable cardiovascular parameters during mitral valve surgery, suggesting it may help manage blood pressure in this context.12345
Is phenylephrine generally safe for humans?
How does phenylephrine differ from other drugs for mitral valve regurgitation?
Research Team
Mario Garcia, MD
Principal Investigator
Montefiore Medical Center
Eligibility Criteria
This trial is for adults over 18 with Mitral Regurgitation (MR) detected on an initial heart scan, who are fit for a more detailed heart scan called transesophageal echocardiography (TEE). People with unstable heart conditions, severe artery disease, recent strokes or high blood pressure aren't eligible.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Administration of phenylephrine during transesophageal echocardiography to assess mitral regurgitation severity
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Phenylephrine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Montefiore Medical Center
Lead Sponsor