MRG007 for Cancer
Recruiting at 14 trial locations
PD
Overseen ByProgram Director
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Lepu Biopharma Co., Ltd.
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
What You Need to Know Before You Apply
What is the purpose of this trial?
This is an open-label, multi-center, phase I study to evaluate the safety, tolerability, efficacy, and pharmacokinetics of MRG007 (ARR-217) in patients with unresectable locally advanced or metastatic solid tumors.
Who Is on the Research Team?
LS
Lin Shen, M.D.
Principal Investigator
Peking University Cancer Hospital & Institute
Are You a Good Fit for This Trial?
This trial is for patients with advanced solid tumors like colorectal, stomach, or pancreatic cancer who have not responded to standard treatments or can't tolerate them. They must be willing to consent, have a life expectancy of at least 3 months, provide a tumor sample for testing, and have at least one measurable lesion. Participants should be relatively active (ECOG score 0-1) and meet certain organ function criteria.Inclusion Criteria
I am willing to sign the consent form and follow the study rules.
My doctor expects me to live for at least 3 more months.
I can provide a tumor sample for CDH17 testing or agree to a biopsy.
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What Are the Treatments Tested in This Trial?
Interventions
- MRG007
Trial Overview The study is testing MRG007 (ARR-217), focusing on its safety, tolerability, effectiveness, and how the body processes it. It's an early-phase trial involving people with serious cancers that are locally advanced or spread elsewhere and cannot be surgically removed.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: MRG007Experimental Treatment1 Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Lepu Biopharma Co., Ltd.
Lead Sponsor
Shanghai Miracogen Inc.
Lead Sponsor
Trials
21
Recruited
2,500+
ArriVent BioPharma, Inc.
Industry Sponsor
Trials
2
Recruited
550+
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