This trial is evaluating whether E7777 will improve 1 primary outcome and 6 secondary outcomes in patients with Lymphoma, Large B-Cell, Diffuse. Measurement will happen over the course of 28 Days Post E7777 infusion.
This trial requires 30 total participants across 4 different treatment groups
This trial involves 4 different treatments. E7777 is the primary treatment being studied. Participants will be divided into 4 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
"The vast majority of cases of HL can be cured with chemotherapy, radiation or surgery alone. Staging factors such as stage, nodal involvement or presence of symptoms at the time of diagnosis have no effect on cure outcomes." - Anonymous Online Contributor
"The cause of lymphoma is not understood, but it is likely that genetics, a high-risk environment, and accumulation of somatic mutations contribute to this devastating cancer." - Anonymous Online Contributor
"Lymphoma is a type of cancer that forms in lymph tissues. It is most commonly found in the kidneys and bones. There are several subtypes, the rarest being Waldenström's Macroglobulinemia." - Anonymous Online Contributor
"Lymphoma in the form of HL, NHL, and Hodgkin disease has a strong genetic component and responds well to radiation, chemotherapy, targeted agents, immunotherapy, and stem cell transplantation. Many patients are able to have a long-term remission of the cancer using these techniques." - Anonymous Online Contributor
"Around 200,000 cancers of non-Hodgkin's lymphoma are detected a year in the United States. Non-Hodgkin lymphoma accounts for 9% of all cancer diagnoses in the United States. The five most common types of non-Hodgkin lymphoma include: large-cell lymphoma (23.6% of non-Hodgkin lymphoma cases), diffuse large B-cell lymphoma (9.4% of non-Hodgkin lymphoma cases), follicular lymphoma (6.7% of non-Hodgkin lymphoma cases), Burkitt's lymphoma (5." - Anonymous Online Contributor
"A doctor’s diagnosis is correct in less than half to a third of the cases. The signs of lymphoma usually appear many months to years before diagnoses and are much milder when lymphoma is suspected. A good way to detect lymphoma before it has been diagnosed is to suspect it from the signs of the lymphoma itself. A major role for lymphoma prevention is obviously to reduce the development of lymphoma and its symptoms by ensuring the cancer-fighting immunity in the people is working as it should." - Anonymous Online Contributor
"The disease progresses at its own alarming speed. Treatment with chemotherapy and/or radiotherapy, if used, will prolong survival by at least several weeks. There is still a long way to go with treatments for lymphomas including chemotherapy, radiotherapy, immunotherapy, stem cell transplants and new approaches that target the tumor cells. It's very rare for lymphoma to be the only problem that a dog is being faced with. However, lymphocytes are the predominant type of cells at the site of tumor formation; consequently, a serious, progressive and fast problem that can spread through the body as the disease progresses is highly probable. And although a lymphocyte can live a long life, a lymphoma is just that." - Anonymous Online Contributor
"Our case showed that it can be successfully treated by chemotherapy which is very cost effective, but if the patient does not accept it, then it will be necessary to get his consent to be eligible for a clinical trial." - Anonymous Online Contributor
"The use of E7777 with chemotherapy for the treatment of relapsed/refractory Hodgkin's disease shows promising responses. Although more research in this field is needed, these preliminary data suggest this medication may also be of benefit in the treatment of relapsed/refractory non-Hodgkin's lymphoma." - Anonymous Online Contributor
"We suggest that patients with lymphoma should be advised to investigate any family members with a history of lymphoma, who also have characteristic immunophenotype or high risk genotypes." - Anonymous Online Contributor
"In the last few years, most clinicians and researchers in the United States have seen great advancements in non-Hodgkin’s lymphoma treatment, the use of chemoprevention, the use of non-invasive imaging techniques for diagnosis and the ability to define remission from the disease. At the same time, there is a general consensus that immunotherapy is the most effective treatment, given the increased number of newly defined types of lymphomas as well as the better understanding of the malignant process." - Anonymous Online Contributor
"There have been several major advances for treating lymphoma in last 2 decades. The ability to assess the tumorous disease precisely and to tailor the treatment to the specific disease type and individual patients, has allowed patients who would not have been eligible for conventional treatments to be offered treatment based on their individual pathophysiology. Also, the better understanding and the characterization of the tumour infiltrating cells have paved the way to new treatment strategies for lymphoma. The immunotherapy (also called immunochemotherapy) involves the stimulation of the patient’s immune system with tumour antigens or cytokines and has led to clinical responses in a subgroup of patients." - Anonymous Online Contributor