130 Participants Needed

BMS-986504 for Non-Small Cell Lung Cancer

Recruiting at 72 trial locations
BS
Fl
Overseen ByFirst line of the email MUST contain NCT # and Site #.
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to evaluate the safety and efficacy of BMS-986504 monotherapy in participants with advanced or metastatic Non-small Cell Lung Cancer (NSCLC) with homozygous MTAP deletion after progression on prior therapies.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Who Is on the Research Team?

BS

Bristol-Myers Squibb

Principal Investigator

Bristol-Myers Squibb

Are You a Good Fit for This Trial?

This trial is for adults over 18 with advanced or metastatic Non-small Cell Lung Cancer (NSCLC) that can't be cured and has worsened after previous treatments. Participants must have a certain type of genetic change in their cancer cells called homozygous MTAP deletion, at least one measurable tumor, and be able to perform daily activities with minimal assistance.

Inclusion Criteria

I am fully active or have some restrictions but can still care for myself.
At least 1 measurable lesion as per RECIST v1.1
My lung cancer is confirmed and lacks MTAP, and I can provide tissue samples.
See 3 more

Exclusion Criteria

I have active brain tumors or cancer in the lining of my brain.
I don't have stomach issues that would affect medication absorption.
Known severe hypersensitivity to study treatment and/or any of its excipients
See 2 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive BMS-986504 monotherapy for advanced or metastatic NSCLC with homozygous MTAP deletion

Up to 3 years

Follow-up

Participants are monitored for safety and effectiveness after treatment

Up to 3 years

What Are the Treatments Tested in This Trial?

Interventions

  • BMS-986504
Trial Overview The study tests BMS-986504 as a solo treatment for NSCLC patients who have the specific MTAP deletion. It aims to see how safe it is and how well it works after other treatments have failed. Patients will take this medication orally, meaning they'll swallow tablets whole.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Arm B: BMS-986504 Dose 2Experimental Treatment1 Intervention
Group II: Arm A: BMS-986504 Dose 1Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Bristol-Myers Squibb

Lead Sponsor

Trials
2,731
Recruited
4,127,000+
Headquarters
New York City, USA
Known For
Oncology & Cardiovascular
Top Products
Eliquis, Opdivo, Revlimid, Orencia
Christopher Boerner profile image

Christopher Boerner

Bristol-Myers Squibb

Chief Executive Officer since 2023

PhD in Business Administration from the Haas School of Business, University of California, Berkeley; BA in Economics and History from Washington University in St. Louis

Deepak L. Bhatt profile image

Deepak L. Bhatt

Bristol-Myers Squibb

Chief Medical Officer since 2024

MD from Yale University; MSc in Clinical Epidemiology from the University of Pennsylvania

Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security