Your session is about to expire
← Back to Search
Regorafenib + Durvalumab for Liver Cancer
Study Summary
This trial is testing whether a combination of two drugs can shrink tumors in patients with high-risk liver cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2019 Phase 1 & 2 trial • 495 Patients • NCT02024607Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- My early-stage cancer was treated successfully with no current signs of it.I can take pills by mouth.I haven't had active disease in the last 5 years and have consulted the study doctor.My liver cancer is at an early to mid-stage according to the AJCC 8th edition.My body weight is over 30 kg.I have a skin condition that doesn't need treatment with pills or injections.I have signed the consent form for this trial within the last 28 days.My liver cancer diagnosis is confirmed by tests or clinical criteria.I am willing and able to follow the study's treatment and visit schedule.I do not have any serious ongoing illnesses that could affect my participation in the study.I have multiple tumors, with at least one larger than 5 cm.I have not received a live vaccine in the last 30 days.My blood clotting tests are normal or managed with medication.I am not on any cancer treatments but may be on hormone therapy for other reasons.My liver cancer is of a specific type (mixed or fibrolamellar).I am eligible for a liver transplant.I have nerve damage that affects my daily activities.I have or had an autoimmune or inflammatory disorder.My cancer was treated with the goal of cure, and I've been free of active disease for 3+ years.My tumor is larger than 2 cm with blood vessel invasion, or I have multiple tumors but none are over 5 cm.I am 18 years old or older.My tumor is larger than 5 cm and has not invaded blood vessels.I am fully active or restricted in physically strenuous activity but can do light work.I do not have an active infection like TB, hepatitis B, or hepatitis C.My kidney function, measured by creatinine or its clearance, is within the required range.My cancer has spread beyond my liver.I have previously been treated with specific immune therapies or other approved drugs for liver cancer.I have not had an upper GI bleed in the last 6 months.I have not had liver treatment in the last 28 days.I have a lasting side effect that won't worsen with durvalumab, as confirmed by a study doctor.I have not had major surgery in the last 28 days.I have had cancer spread to the lining of my brain and spinal cord.I haven't taken immunosuppressive drugs in the last 14 days.I am not pregnant or breastfeeding and willing to use birth control during and up to 90 days after treatment.My liver functions well despite my illness.I am HIV positive and currently on antiretroviral therapy.My thyroid condition is stable with medication.I have had cancer before, but it was a different type than my current diagnosis.I had skin cancer (not melanoma) treated and currently show no signs of it.I don't have lasting side effects from cancer treatment, except for hair loss or skin changes.
- Group 1: Treatment (regorafenib, durvalumab)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there still any unfilled positions in this clinical trial?
"This study is not presently looking for new participants. The trial was initially posted on March 1st, 2023 and was last updated on September 23rd, 2022. However, there are 2683 other trials actively enrolling patients with liver carcinoma and 397 different trials for Regorafenib that are currently recruiting."
Has Regorafenib been cleared by the FDA for public consumption?
"We have given Regorafenib a score of 2, as there is evidence to support its safety but not efficacy."
What does the research say about Regorafenib's efficacy?
"The original research on regorafenib was conducted in 2010 by the City of Hope. As of right now, there are 188 completed studies and 397 clinical trials still recruiting patients. A large concentration of these active trials are located in Urbana, Illinois."
At how many sites can volunteers enroll in this research project?
"The trial is being conducted at Carle Cancer Center NCI Community Oncology Research Program in Urbana, Illinois, Medical College of Wisconsin in Milwaukee, Wisconsin, and Emory University Hospital/Winship Cancer Institute in Atlanta, Georgia as well other 5 undisclosed locations."
How many individuals are currently a part of this research project?
"Unfortunately, this particular clinical trial is not seeking patients at the moment. It was initially posted on March 1st 2023 and last updated September 23rd 2022. However, there are 2683 other trials involving liver carcinoma that are recruiting right now and 397 for Regorafenib."
Why is Regorafenib typically given to patients?
"Regorafenib is most often prescribed to patients who have already undergone treatment with anti-VEGF drugs. It can also be used as a sorafenib alternative for patients with metastatic colorectal cancer (CRC) and other advanced directives."
Share this study with friends
Copy Link
Messenger