This trial is evaluating whether Aerobic walking will improve 6 primary outcomes, 19 secondary outcomes, and 1 other outcome in patients with Parkinson Disease. Measurement will happen over the course of Change from Baseline motor experiences of daily living score at 1 year.
This trial requires 100 total participants across 2 different treatment groups
This trial involves 2 different treatments. Aerobic Walking is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 & 3 and have had some early promising results.
About 1 percent of the population of the United States is affected by Parkinson disease at some point in their life. Patients are at an increased risk for developing dementia with the onset of the disease. As many as 85 percent of patients require some form of care 1 month after diagnosis. If current trends continue, by the year 2100 more than one in every five people in the United States will have Parkinson's disease.
Neurological symptoms of Parkinson's disease are usually not cured in the course of the disease, although improvements can occur in some respects. The only cure for the disease seems to be removal of the disease itself.
Parkinson disease is a neurological disorder characterized by movement problems, such as tremors and muscle rigidity which occur in a cluster. Roughly 1 in 250 people in the USA will develop Parkinson disease during their life.\n
Drugs for Parkinson's disease are often not the first choices of treatment. For the majority to treat pain, a non opioid alternative, such as palliative care should be sought.
Probably there are many causes for PD, many shared among patients; but some factors may differ according to gender or familial history of PD. It appears, however, that the risk factor "older age at onset of PD" is strongly correlated with the severity (fast progression).
As PD progresses, both symptoms and signs worsen. As the disease progresses, symptoms usually become more severe and more of daily living is affected. The severity of symptoms increases for as long as the disease is present. Although most people with PD remain in their homes after diagnosis, the prevalence of nursing home stays among people with PD is rising and likely to continue to increase. Over one-fifth of people with PD require nursing home care. The signs of advanced PD are progressive and irreversible and include weakness of muscles and limbs, stiff joints, trouble walking, slow speech, and difficulty swallowing.
A study of more than 2,000 adults with stroke found exercise of any type was associated with a significant improvement in walking performance in the 6-MWT. In children with CP, walking velocity increased to >1,000 meters/min.
Frequent and long-term aerobic walking has a profound effects on the cardiovascular health risks, in particular cardiovascular rehabilitation programs in the primary care should include, besides the physical and lifestyle advice, the prevention of cardiovascular diseases as we do for walking exercise.
There is no current research that provides the most up-to-date information about the management and treatment of PD. Patients and clinicians need to be aware of available treatments and evidence in order to make informed decisions. We also need more studies that address PD’s natural history, pathophysiology, and quality of life in this disease.
Parkinsonism appears to run in families. It is not rare for a first-degree relative to have developed the disease. A major part of the variance in disease severity can be attributed to genetic factors.
Most studies on the topic are limited by small sample size, lack of baseline measures, and short follow-up. The large proportion of nonscientists (and possibly even nonmedical health professionals) in the study samples suggests a need for improved methods related to health professions participation in clinical trials and for more general education of the public as to how to participate in clinical trials.
The use of walking with other treatment modalities is not prevalent. While walking is an integral part of treatment for Parkinson's disease, it is not widely used as a form of treatment in PD in combination with other treatments.