Odor Representation for Smell Identification
What You Need to Know Before You Apply
What is the purpose of this trial?
To identify a neural representation of odor identity, it is necessary to dissociate molecular structure from perceptual identity/similarity.
Whether the olfactory system employs a coding scheme in which the similarity between neural features is systematically related to perceptual similarity is unknown. Experiments for this aim will acquire perceptual responses while manipulating perceptual similarity. In Experiment 1A, we will examine features of neural responses during natural behavior of freely naming odors. In Experiment 1B, we will manipulate perceptual similarity with odor metamers and collect perceptual and neural data on each trial. Preliminary data suggest that the earliest, high-frequency components of the piriform response can optimally decode perceptual identity.
Who Is on the Research Team?
christina zelano
Principal Investigator
Northwestern University
Are You a Good Fit for This Trial?
This study is for English-speaking individuals aged 12 to 65 who are undergoing brain surgery for epilepsy that can't be controlled with medication. It aims to understand how the brain processes smells.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Experiment 1A
Examine features of neural responses during natural behavior of freely naming odors
Experiment 1B
Manipulate perceptual similarity with odor metamers and collect perceptual and neural data
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Odor
Trial Overview
The trial is investigating how our brains recognize different odors and if neural responses during smell identification relate to our perception of odor similarity. Participants will freely name odors and evaluate perceptual similarities between them.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Odors will be presented and identified
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor
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