Peas in Chili for Blood Sugar and Appetite Control

(PEA5 Trial)

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: St. Boniface Hospital

Must not be taking: Corticosteroids, Stomach acid-lowering, Laxatives, others

Disqualifiers: Diabetes, Cardiovascular disease, Liver disease, others

Compensation: Varies

Number of Visits: 4

Duration: Approximately 4-8 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests different types of chili to determine their effects on blood sugar levels and feelings of fullness. Participants will try chili made with rice, split yellow peas, or whole yellow peas. The goal is to discover if certain pea varieties can help manage blood sugar and appetite. Individuals who are generally healthy and regularly eat breakfast, lunch, and dinner may be suitable for this study. As an unphased trial, this study provides a unique opportunity to contribute to nutritional research that could enhance dietary recommendations.

Do I have to stop taking my current medications for the trial?

The trial requires that you do not use any prescription or non-prescription drugs, herbal, or nutritional supplements known to affect blood sugar or appetite. If you're taking such medications, you may need to stop them to participate.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that yellow peas, whether whole or split, are generally easy to digest when used in chili. Studies have found that yellow peas have a low impact on blood sugar levels, aiding in blood sugar management without major side effects.

Yellow peas are also high in protein and fiber. These nutrients help control blood sugar and keep individuals feeling full longer. Studies on yellow pea products have reported no major negative effects, suggesting they are safe to consume in typical study amounts.

In summary, evidence suggests that chili made with whole or split yellow peas is safe to eat. However, since individual responses vary, consulting a healthcare provider is advisable if there are any concerns. ^{1 2 3 4 5}

Why are researchers excited about this trial's treatments?

Researchers are excited about these treatments because they introduce a novel approach to managing blood sugar and appetite using ingredients that are both accessible and natural. Unlike typical treatments for blood sugar control, which might involve medications like metformin or insulin, these chili-based treatments use whole and split yellow peas, which are rich in fiber and have a low glycemic index, potentially leading to better blood sugar regulation and increased satiety. The use of peas could offer a more natural dietary intervention with fewer side effects, providing a new, food-based strategy to help people manage their blood sugar and appetite effectively.

What evidence suggests that this trial's treatments could be effective for blood sugar and appetite control?

This trial will compare the effects of different types of chili on blood sugar and appetite control. Studies have shown that yellow peas can help manage blood sugar levels and control appetite. Research indicates that meals with yellow peas, whether whole or split, cause a smaller increase in blood sugar after eating compared to other meals. For example, one study found that blood sugar levels were much lower when people ate soup with peas instead of soup with potatoes. Other research highlights that the protein and fiber in yellow peas are important for these effects. In this trial, participants will receive either whole yellow pea chili, split yellow pea chili, or rice chili. Overall, adding yellow peas to meals like chili might help keep blood sugar steady and reduce hunger. ^{1 6 7 8 9}

Who Is on the Research Team?

Heather Blewett, PhD

Principal Investigator

Agriculture and Agri-Food Canada

Are You a Good Fit for This Trial?

This trial is for generally healthy men and women aged 18-40, with a BMI of 18.5-30. They should regularly eat three meals a day and be willing to follow the study's requirements after giving informed consent.

Inclusion Criteria

Habitually consume breakfast, lunch and dinner in the morning, mid-day and evening, respectively.

Willing to provide informed consent;

Willing/able to comply with the requirements of the study.

Exclusion Criteria

Pregnant or lactating

I am unwilling or unable to eat the foods required for the study.

I have not had major surgery in the last 3 months.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants attend 4 clinic visits in a fasted state to consume chili with peas or rice and provide blood and urine samples, complete questionnaires, and have their calorie intake measured.

Approximately 4-8 weeks

4 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Rice chili
• Split yellow pea chili
• Whole yellow pea chili

Trial Overview The study tests how different types of chili containing whole yellow peas, split yellow peas, or rice affect blood sugar levels and feelings of fullness in volunteers after they eat.

How Is the Trial Designed?

Group I: Whole yellow pea Experimental Treatment 1 Intervention

Chili containing 25g available carbohydrate from whole yellow peas. Intervention: Whole yellow pea chili

Group II: Split yellow pea Experimental Treatment 1 Intervention

Chili containing 25g available carbohydrate from split yellow peas. Intervention: Split yellow pea chili

Group III: Rice-Satiety Placebo Group 1 Intervention

Rice chili with the same calories as the pea chili. Intervention: Rice chili

Group IV: Rice-PPGR Placebo Group 1 Intervention

Chili containing 25g available carbohydrate from long grain white rice. Intervention: Rice chili

Who Is Running the Clinical Trial?

St. Boniface Hospital

Lead Sponsor

Trials

55

Recruited

15,000+

Agriculture and Agri-Food Canada

Collaborator

Trials

35

Recruited

2,300+

University of Manitoba

Collaborator

Trials

628

Recruited

209,000+

Citations

1. clinicaltrial.be clinicaltrial.be/en/details/76155?active_not_recruiting=1&completed=0&enrolling_by_invitation=1&only_active=0&only_eligible=0&only_recruiting=0&per_page=20

Effect of Peas in Chili on Blood Glucose and Appetite Con... A randomized, controlled, cross-over study designed to examine the PPGR and appetite related sensations to peas in chili will be conducted ...

2. clinicaltrials.gov clinicaltrials.gov/study/NCT02552823

NCT02552823 | Effects of Peas on Blood Glucose Control A health claim for PPGR would increase market demand for peas, and help those who want to limit the rise in blood sugar after a meal choose products to meet ...

3. clinicaltrial.be clinicaltrial.be/nl/details/76155?only_active=0&only_eligible=0&only_recruiting=0&per_page=100

Effect of Peas in Chili on Blood Glucose and Appetite Con... A randomized, controlled, cross-over study designed to examine the PPGR and appetite related sensations to peas in chili will be conducted at the I.H. Asper ...

4. profils-profiles.science.gc.ca profils-profiles.science.gc.ca/en/publication/incorporating-yellow-peas-soup-muffins-and-chili-significantly-reduces-post-prandial

Incorporating yellow peas into soup, muffins and chili ... Compared to soup made with potato, glucose iAUC was significantly decreased (p<.0001) by 46-49% when participants ate soup containing peas.

5. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/22916818/

The effect of yellow pea protein and fibre on short-term ... In conclusion, protein is the component responsible for the short-term effects of yellow peas in the regulation of glycaemia and FI, but its second-meal effects ...

6. cambridge.org cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-yellow-pea-protein-and-fibre-on-shortterm-food-intake-subjective-appetite-and-glycaemic-response-in-healthy-young-men/EE7D8B806761B876F5792192BB6C7874

The effect of yellow pea protein and fibre on short-term ... In conclusion, protein is the component responsible for the short-term effects of yellow peas in the regulation of glycaemia and FI, but its ...

7. utoronto.scholaris.ca utoronto.scholaris.ca/bitstreams/433c58bc-833c-4044-8e5f-9d9fc78d86ad/download

effect of yellow pea protein and fibre on short-term food ... The purpose of this research project is to determine the effect of eating yellow pea fibre and protein on blood sugar and appetite in young men. This study ...

8. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/25302637/

Acute Effects of Pea Protein and Hull Fibre Alone ... This trial supports the use of pea components as value-added ingredients in foods designed to improve glycemic control.

9. researchgate.net researchgate.net/publication/230731683_The_effect_of_yellow_pea_protein_and_fibre_on_short-term_food_intake_subjective_appetite_and_glycaemic_response_in_healthy_young_men

The effect of yellow pea protein and fibre on short-term ... Pulses are low-glycaemic foods rich in protein (20-25 %), resistant starch and fibre that suppress appetite and glycaemia.