145 Participants Needed

ZW191 for Advanced Cancers

Recruiting at 15 trial locations
ZC
Overseen ByZymeworks Clinical Trial Resource
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The purpose of this study is to find out if ZW191 is safe and can treat participants with advanced cancers, including ovarian, endometrial, and non-small cell lung cancers.

Will I have to stop taking my current medications?

The trial information does not specify if you need to stop taking your current medications. However, if you are on treatments for severe infections or have received certain cancer treatments before, it might affect your eligibility.

Research Team

SR

Syed Raza, MD

Principal Investigator

Zymeworks BC Inc.

Eligibility Criteria

This trial is for people with advanced cancers like ovarian, endometrial, and non-small cell lung cancer. Participants must have a confirmed diagnosis of these cancers that are advanced or metastatic, measurable by certain criteria (RECIST v1.1), good heart function (LVEF ≥ 50%), and be in fairly good health overall (ECOG score of 0 or 1).

Inclusion Criteria

My organs are functioning well.
My heart pumps well, with an ejection fraction of 50% or higher.
My cancer is advanced, cannot be surgically removed, has come back, or has spread.
See 2 more

Exclusion Criteria

I do not have another cancer that is getting worse or needs treatment.
I do not have severe or active infections needing treatment.
I have been treated with a TOPO1i antibody drug before.
See 1 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment Part 1

Evaluation of safety and tolerability of ZW191

3 weeks

Treatment Part 2

Further evaluation of safety and exploration of anti-tumor activity of ZW191

Up to approximately 2 years

Follow-up

Participants are monitored for safety and effectiveness after treatment

Up to approximately 2 years

Treatment Details

Interventions

  • ZW191
Trial OverviewThe study is testing ZW191 to see if it's safe and effective for treating participants with specific types of advanced cancers. It aims to understand the appropriate dosage and assess how well tumors respond to this treatment.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: ZW191Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Zymeworks BC Inc.

Lead Sponsor

Trials
6
Recruited
1,300+