180 Participants Needed

ZL-6201 for Cancer

ZS
Overseen ByZL-6201-001 Study Team
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Zai Lab (Shanghai) Co., Ltd.
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to evaluate the safety and tolerability of investigational study drug ZL-6201 for treating sarcoma and solid tumors cancer.

Are You a Good Fit for This Trial?

Adults over 18 with certain types of advanced sarcoma or solid tumors can join this trial. They should be relatively healthy (ECOG status 0 or 1), have a life expectancy over three months, and have received limited prior treatments (no more than 3 for solid tumors, no more than 2 for sarcomas). Participants need measurable cancer lesions, good organ function, and must not have HIV/HBV/HCV. A biopsy is required before treatment starts.

Inclusion Criteria

I've had 3 or fewer treatments for my cancer after it spread or didn't respond to treatment.
I do not have HIV, hepatitis B, or hepatitis C.
I am over 18, can care for myself with minimal help, and expected to live more than 3 months.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive ZL-6201 as a single agent in 21-day cycles to evaluate safety, tolerability, and preliminary efficacy

36 months
Visits every 21 days for each cycle

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • ZL-6201

Trial Overview

The study tests ZL-6201's safety and how well it works in treating sarcoma and other solid tumor cancers. It's an early-phase trial to see how patients tolerate the drug and to observe any preliminary signs of its effectiveness against these cancers.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: ZL-6201Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Zai Lab (Shanghai) Co., Ltd.

Lead Sponsor

Trials
30
Recruited
3,800+

Zai Lab (US) LLC

Industry Sponsor

Trials
3
Recruited
450+