This trial is evaluating whether GSK4381562 will improve 4 primary outcomes and 17 secondary outcomes in patients with Cancer. Measurement will happen over the course of Up to 21 days.
This trial requires 126 total participants across 2 different treatment groups
This trial involves 2 different treatments. GSK4381562 is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
What we do to people with cancer is called “medical treatment” – medical oncologists or MDs, Radiation Oncologists, Radiation Therapists, and Pathologists) – in the U.S., we mostly do surgery, Radiation Oncology, Chemotherapy, and Pathology/histology tests as I have found (but don’t know whether others do the same) some people will be cured, some will be dead within a few years, a majority of them will be dead within five years…If we treat people with cancer, we may even save them and thereby prevent them or their families from feeling as much stress or grief as they will.
Cancer is generally detected early, when it can be cured with a success rate of over 90%. Most men with stage 4 cancer cannot be cured of their cancer because it can be detected too late. However, many people with cancer can be cured if the cancer is caught early enough.
Over 200,000 patients are diagnosed with cancer each year. theme: survival analysis question: Survival after pancreaticoduodenectomy for benign disease. answer: Survival rates after PD have increased substantially since the 1970s, and PD for benign disease is now well-established procedure often offering prolonged survival.
Many cancer cases are caused by environmental, behavioural, biochemical, infectious or genetic factors. Current smoking is the strongest risk factor for most cancers. People of low socio-economic status tend to smoke more intensely, and many cancers have a strong link to diet. Cancer can also be prevented; screening is effective for many common cancers. It is particularly important for women with breast cancer.
Cancer is a disease wherein the most common sign is a change in a tumour; usually it is an enlarged tumour.\n\n- List of cutaneous conditions"
Approximately 25% of children and teens with cancer have cancer-related symptoms. Symptoms can be a complication or result of treatment and include hair loss, poor appetite, fatigue, and bone pains. Many common cancers can have serious long-term effects on kids and teens and even their lives.\n
Cancer incidence, cancer-specific mortality, and overall mortality decreased with increasing age until age 85 years. Most of the decreases were in all-cause mortality, and cancer mortality decreased slightly, irrespective of age, after age 75 years.
This clinical investigation has provided consistent and favourable safety and PK results to date confirming that gsk4381562 is acceptable to administer to patients with a variety of different tumour types, in conjunction with paclitaxel. Gsk4381562 does not impair plasma concentration of paclitaxel.
As we conclude in the paper, the current study and pooled analysis showed that gsk4381562 is effective in improving symptoms and health-related quality of life and may reduce deterioration of these parameters at the end of life. However, we can also state that the study was not designed to prove efficacy or safety. In order to better understand the clinical efficacy of gsk4381562, it must be compared with some currently available drugs of the same kind of the same purpose as a standard to which to compare (see below).
GSK-5381562 exhibited a statistically significant effect modifier when added to FOLFIRINOX chemotherapy alone in the first-line treatment of mCRC. Randomized controlled trials are needed to confirm these findings.
These data provide evidence supporting a clinical benefit for gsk4381562 when given over the course of a week in combination with a taxane chemotherapy regimen. Patients’ experience of side effects of gsk4381562 were largely outweighed by their overall improvement in QoL.
There is not enough evidence to demonstrate benefit of GSK4381562 in cancer patients. No significant difference in overall survival was noted between treatment and control groups in the study by the FOURS. No conclusive evidence has been found of efficacy or safe use of this drug in cancers with mutations in the p53 gene.