← Back to Search

Virus Therapy

Trichuris trichiura Eggs for Whipworm Infection

Phase 1
Waitlist Available
Research Sponsored by George Washington University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Males or females between 18 and 45 years, inclusive
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up weeks 12 through 26 post-chti
Awards & highlights

Study Summary

This trial tests the safety and effectiveness of an experimental product to cause infection with an intestinal nematode in adults to determine the optimal dosage.

Who is the study for?
Healthy adults aged 18-45 who have never had a whipworm infection can join this trial. They must be in good health, not pregnant or breastfeeding, willing to use contraception if applicable, and available for about 7.5 months. People with immune deficiencies, liver or kidney issues, substance abuse history within the last two years, certain psychiatric conditions, blood disorders or other significant health problems cannot participate.Check my eligibility
What is being tested?
The study is testing the safety of swallowing Trichuris trichiura eggs (a type of worm) to see if it causes a controlled infection without harm. Participants will take different doses to find the safest amount that still leads to detectable whipworm infection.See study design
What are the potential side effects?
Potential side effects may include digestive discomfort or symptoms related to a mild parasitic infection since participants will ingest whipworm eggs. The exact side effects are being studied as part of this research.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 45 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~weeks 12 through 26 post-chti
This trial's timeline: 3 weeks for screening, Varies for treatment, and weeks 12 through 26 post-chti for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Adverse Events of Special Interest
Adverse events related to abnormal clinical safety laboratory parameter (absolute eosinophil count) values
Adverse events related to abnormal clinical safety laboratory parameter (hemoglobin concentration) values
+8 more
Secondary outcome measures
Fecal egg counts
Fecal egg detection
T. trichiura DNA in fecal samples
Other outcome measures
Cytokine concentrations of supernatants after stimulation of peripheral blood mononuclear cells (PBMCs) with T. trichiura antigen
Fecal microbiome
Serum cytokine concentrations

Trial Design

3Treatment groups
Experimental Treatment
Group I: Trichuris trichiura Egg Inoculum 450 eggsExperimental Treatment1 Intervention
450 Trichuris trichiura eggs
Group II: Trichuris trichiura Egg Inoculum 300 eggsExperimental Treatment1 Intervention
300 Trichuris trichiura eggs
Group III: Trichuris trichiura Egg Inoculum 150 eggsExperimental Treatment1 Intervention
150 Trichuris trichiura eggs

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

George Washington UniversityLead Sponsor
241 Previous Clinical Trials
453,279 Total Patients Enrolled
National Institute of Allergy and Infectious Diseases (NIAID)NIH
3,261 Previous Clinical Trials
5,482,988 Total Patients Enrolled

Media Library

Trichuris trichiura Egg Inoculum (Virus Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05706116 — Phase 1
Whipworm Infection Research Study Groups: Trichuris trichiura Egg Inoculum 150 eggs, Trichuris trichiura Egg Inoculum 300 eggs, Trichuris trichiura Egg Inoculum 450 eggs
Whipworm Infection Clinical Trial 2023: Trichuris trichiura Egg Inoculum Highlights & Side Effects. Trial Name: NCT05706116 — Phase 1
Trichuris trichiura Egg Inoculum (Virus Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05706116 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals aged 60 or older being admitted to this medical experiment?

"This trial has set an age requirement of 18 to 45 for its potential participants, adhering to the established requirements for entry."

Answered by AI

Are there currently vacancies available for individuals to partake in this research?

"According to the information present on clinicaltrials.gov, this medical trial is not recruiting patients at the moment. It was first posted on March 1st of 2023 and last adjusted on January 20th of the same year. However, there are currently 745 other trials that are actively searching for volunteers."

Answered by AI

How detrimental is the ingestion of Trichuris trichiura Egg Inoculum 150 eggs to human health?

"Due to the early stage of clinical trials, data regarding Trichuris trichiura Egg Inoculum 150 eggs' safety and efficacy is limited, thus receiving a score of 1."

Answered by AI

Under what conditions can individuals participate in this clinical study?

"This clinical trial seeks 18 individuals with whipworm infection aged between 18 and 45. To qualify, applicants must be male or female within the specified age range, in good health as indicated by screening processes, willing to commit for an estimated 7.5 months, and consenting to participate after reading all relevant documents."

Answered by AI
~12 spots leftby Jul 2026