Itraconazole and MK-2828 for Drug Interaction Study
What You Need to Know Before You Apply
What is the purpose of this trial?
The main goals of this study are:
* To learn what happens to one dose of MK-2828 in a healthy person's body over time when it is taken with itraconzole
* To learn what happens to one dose of midazolam in a healthy person's body over time when it is taken with MK-2828
Researchers want to learn if the levels of MK-2828 in the body are about the same when MK-2828 is taken with itraconazole as when it is taken alone. They also want to know if taking MK-2828 more than once affects how much midazolam is in the body after a single dose.
Who Is on the Research Team?
Medical Director
Principal Investigator
Merck Sharp & Dohme LLC
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Part 1: Itraconazole Treatment
Participants receive multiple oral doses of Itraconazole with a single oral dose of MK-2828
Part 2: Midazolam Treatment
Participants receive multiple oral doses of MK-2828 with a single oral dose of midazolam
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Itraconazole
- Midazolam
- MK-2828
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants will receive multiple oral doses of MK-2828 with a single oral dose of midazolam.
Participants will receive multiple oral doses of Itraconazole with a single oral dose of MK-2828.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Merck Sharp & Dohme LLC
Lead Sponsor
Chirfi Guindo
Merck Sharp & Dohme LLC
Chief Marketing Officer since 2022
Degree in Engineering from Ecole Centrale de Paris, MBA from New York University Stern School of Business
Robert M. Davis
Merck Sharp & Dohme LLC
Chief Executive Officer since 2021
JD from Northwestern University Pritzker School of Law, MBA from Northwestern University Kellogg Graduate School of Management, Bachelor's in Finance from Miami University
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