Study Summary
This trial is testing a new virus treatment for brain cancer. The virus is made to only attack cancer cells, and not healthy cells.
- Recurrent Anaplastic Astrocytoma
- Gliosarcoma
- Isocitrate Dehydrogenase 1 Wildtype Allele
- Glioblastoma (GBM)
- Brain Tumor
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
2 Primary · 5 Secondary · Reporting Duration: Up to 1 year
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
2 Treatment Groups
Part II (oncolytic adenovirus Ad5-DNX-2401, surgery)
1 of 2
Part I (oncolytic adenovirus Ad5-DNX-2401)
1 of 2
Experimental Treatment
36 Total Participants · 2 Treatment Groups
Primary Treatment: Therapeutic Conventional Surgery · No Placebo Group · Phase 1
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Chen, Stephen R, Melissa M Chen, Chibawanye Ene, Frederick F Lang, and Peter Kan. 2021. “Perfusion-guided Endovascular Super-selective Intra-arterial Infusion for Treatment of Malignant Brain Tumors”. Journal of Neurointerventional Surgery. BMJ. doi:10.1136/neurintsurg-2021-018190.
- Chen, Stephen R, Melissa M Chen, Chibawanye Ene, Frederick F Lang, and Peter Kan. 2021. “Perfusion-guided Endovascular Super-selective Intra-arterial Infusion for Treatment of Malignant Brain Tumors”. Journal of Neurointerventional Surgery. BMJ. doi:10.1136/neurintsurg-2021-018190.
- 2019. "MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03896568.
Frequently Asked Questions
Has the FDA given sign-off to Therapeutic Conventional Surgery?
"The safety of Therapeutic Conventional Surgery is estimated to be a 1 given the limited evidence currently available. This is supported by its Phase 1 trial status, which suggests few studies have been conducted on efficacy and safety." - Anonymous Online Contributor
Are there any spots open to join this research endeavor?
"Affirmative. According to the information found on clinicaltrials.gov, this medical study is actively recruiting participants since its posting date on February 12th 2019 and latest update on August 11th 2022. This clinical trial seeks 36 patients from one location specifically." - Anonymous Online Contributor
How many individuals can enrol in this clinical experiment?
"Affirmative. As reported on clinicaltrials.gov, this medical trial is presently recruiting participants and was first posted on February 12th 2019 with the most recent edit being made on August 11th 2022. The research team needs to enroll 36 patients from one centre." - Anonymous Online Contributor