28 Participants Needed

Gentle Moves for Mild Cognitive Impairment and Dementia

(Pro-Home MeC Trial)

LY
NM
Overseen ByNaoko Muramatsu, PhD
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: University of Illinois at Chicago
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Do I need to stop taking my current medications to join the trial?

The trial protocol does not specify whether you need to stop taking your current medications.

What data supports the idea that Gentle Moves for Mild Cognitive Impairment and Dementia is an effective treatment?

The available research shows that exercise and activity-based treatments can be beneficial for people with mild cognitive impairment and dementia. For example, a study on a similar exercise program found that participants improved in their ability to stand on one leg and complete a simple walking test, which are indicators of better balance and mobility. This suggests that exercise programs like Gentle Moves could help improve physical abilities in people with these conditions. However, the research does not provide specific data on Gentle Moves itself, so more studies are needed to confirm its effectiveness.12345

What safety data exists for Gentle Moves in treating mild cognitive impairment and dementia?

The research provided does not directly address the safety data for Gentle Moves specifically. However, it includes studies on dance movement interventions and exercise routines for individuals with mild cognitive impairment and dementia, which are related to Gentle Moves. These studies suggest that such interventions are feasible and may improve cognitive function and promote activity and independence, but specific safety data for Gentle Moves is not detailed in the provided research.56789

Is Gentle Moves a promising treatment for mild cognitive impairment and dementia?

Gentle Moves could be a promising treatment because exercise and movement therapies have shown potential benefits for people with mild cognitive impairment and dementia. These therapies can help improve quality of life, balance, and social engagement, which are important for people with these conditions.25101112

What is the purpose of this trial?

The objective of the proposed study, "Promoting In-Home Activities at a Memory \& Aging Clinic (Pro-Home MeC)", is to assess and improve the feasibility of a physical activity (PA) intervention and the measurement of cognitive outcomes in a memory clinic setting for inactive older adults with mild cognitive impairment (MCI) or mild dementia and to examine how and improve the feasibility and acceptability of the procedures.

Eligibility Criteria

This trial is for people aged 50 or older who speak English and have been diagnosed with mild cognitive impairment (MCI) or mild dementia. They should be physically inactive, doing less than 150 minutes of planned exercise per week, and able to sit independently for at least 15 minutes. Those with significant mental or physical disabilities, severe hearing or vision loss, insufficient decision-making capacity, lack of safety awareness, current participation in similar research, or unwillingness to be assigned randomly can't join.

Inclusion Criteria

Fluent in English
I am 50 years old or older.
Physically inactive (< 150 min/wk of planned PA)
See 2 more

Exclusion Criteria

I have a disability that makes it unsafe for me to do physical activities.
I have severe hearing or vision loss that is not treated.
I have difficulty recognizing safety hazards.
See 3 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a three-month physical activity intervention called 'Gentle Moves'

12 weeks
In-home activities

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Gentle Moves
Trial Overview The 'Pro-Home MeC' study tests a physical activity program called 'Gentle Moves' designed for older adults with MCI or mild dementia in a memory clinic setting. The goal is to see if the program is doable and liked by participants while also checking its effect on brain function.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Gentle MovesExperimental Treatment1 Intervention
Three-month physical activity intervention.
Group II: Usual CareActive Control1 Intervention
Usual care provided by neuropsychologist.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Illinois at Chicago

Lead Sponsor

Trials
653
Recruited
1,574,000+

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+

Findings from Research

The StandingTall exercise program, delivered via tablet, was found to be feasible and safe for older adults with dementia, with a usability score of 68, indicating it met the target for usability.
Participants showed increasing adherence to the program over 12 weeks, with some exercising over 115 minutes by the end, and only one minor fall occurred without injury, suggesting the program is safe for this population.
Pilot feasibility study of a home-based fall prevention exercise program (StandingTall) delivered through a tablet computer (iPad) in older people with dementia.Taylor, ME., Close, JCT., Lord, SR., et al.[2022]
The PrAISED intervention, which involved up to 50 therapy sessions focusing on exercise and functional activities for adults with early dementia or mild cognitive impairment, did not show significant improvements in daily living activities, physical activity, or quality of life compared to usual care after 12 months.
Although the intervention group experienced fewer falls (79 falls) compared to the control group (200 falls), the difference was not statistically significant, indicating that the exercise program did not effectively reduce fall risk or improve overall health outcomes.
Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial.Harwood, RH., Goldberg, SE., Brand, A., et al.[2023]
A 16-week dyadic Tai Chi exercise program was successfully completed by 86.4% of Alzheimer's disease (AD) patients, indicating high adherence and potential for safety in exercise interventions for this population.
Participants showed significant improvements in fall-risk-related functional mobility, with Unipedal Stance Time increasing from 4.0 to 5.6 seconds and Timed Up and Go times improving from 13.2 to 11.6 seconds, suggesting that Tai Chi may enhance mobility and reduce fall risk in individuals with dementia.
Fall risk-relevant functional mobility outcomes in dementia following dyadic tai chi exercise.Yao, L., Giordani, BJ., Algase, DL., et al.[2022]

References

Pilot feasibility study of a home-based fall prevention exercise program (StandingTall) delivered through a tablet computer (iPad) in older people with dementia. [2022]
Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial. [2023]
Fall risk-relevant functional mobility outcomes in dementia following dyadic tai chi exercise. [2022]
Does physical exercise improve the capacity for independent living in people with dementia or mild cognitive impairment: an overview of systematic reviews and meta-analyses. [2023]
A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) - A Protocol. [2021]
Assessment of balance in mild and moderate stages of Alzheimer's disease: implications on falls and functional capacity. [2022]
Motor function in subjects with mild cognitive impairment and early Alzheimer's disease. [2022]
Effects of a specially designed aerobic dance routine on mild cognitive impairment. [2022]
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer's disease, and dementia: A systematic scoping review and meta-analysis. [2023]
The relative effectiveness of different types of exercise for people with Mild Cognitive Impairment or dementia: Systematic review protocol. [2021]
The effects of the music-with-movement intervention on the cognitive functions of people with moderate dementia: a randomized controlled trial. [2022]
Improvisational Movement to Improve Quality of Life in Older Adults With Early-Stage Dementia: A Pilot Study. [2022]
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