High-Fat Diet for Insulin Resistance
(MetFlexHFD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how a high-fat diet affects the body's response to blood sugar after eating. Participants will follow a hypercaloric, high-fat diet for three days to assess its impact on sugar processing compared to a regular diet. The study will also explore whether biological sex influences these effects. This trial suits adults aged 20-45 who are generally healthy and not on certain medications or diets. Participants should not have food allergies or a history of disordered eating. As an unphased study, this trial offers participants the chance to contribute to foundational research that could enhance dietary guidelines.
Will I have to stop taking my current medications?
Yes, you will need to stop taking certain medications, including antioxidant supplements, prescription anti-inflammatory drugs, antibiotics, steroids, probiotics, and medications for cholesterol, diabetes, or weight management.
What prior data suggests that this high-fat diet is safe for healthy adults?
Research has shown that high-fat diets are generally safe for short-term use in people. Studies have found that consuming a lot of fats doesn't cause immediate harm, though less is known about long-term effects. For example, one study found that while a high-fat diet can make it harder for the body to process sugar, it doesn't seem to have major health impacts in the short term. Another source suggests that these diets can lead to weight gain and make it harder for the body to use insulin, but they are not harmful when used briefly.
In this trial, participants will follow a high-fat diet for just three days, aligning with the short-term use studied in research. This approach is likely to be well-tolerated by participants without serious side effects.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores how a hypercaloric, high-fat diet can impact insulin resistance in a new way. Unlike standard treatments for insulin resistance, which often focus on medication or low-calorie diets to lower blood sugar and improve insulin sensitivity, this approach increases calorie and fat intake to see its effects on the body. By consuming 165% of daily energy needs with 65% of those calories from fat, the trial could reveal insights into how high-fat consumption affects insulin regulation. This unique perspective could lead to a better understanding of dietary impacts on insulin resistance.
What evidence suggests that this high-fat diet is effective for studying insulin resistance?
Research has shown that consuming a lot of fat can affect how the body uses insulin, which is crucial for controlling blood sugar. A high-fat diet may impair insulin function. This trial will investigate the effects of a hypercaloric, high-fat diet on insulin resistance. One study found that such a diet can lead to weight gain and increased body fat, but it did not alter sugar absorption. Another study suggested that eating a high-fat diet for a month can reduce the body's responsiveness to insulin, making it harder to manage sugar levels after meals. Overall, high-fat diets might decrease the body's ability to handle sugar effectively.678910
Who Is on the Research Team?
Matthew D Barberio, PhD
Principal Investigator
George Washington University
Are You a Good Fit for This Trial?
This trial is for healthy adults aged 20-45 with a BMI of 18.5-29.9, who are at low risk for medical complications and food insecurity. It's not suitable for those outside this age range or BMI, or those at higher risk based on specific health screenings.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Dietary Intervention
Participants consume a high-fat diet to decrease insulin sensitivity
Metabolic Testing
Whole-body metabolism is measured during a standard 75-gram oral glucose tolerance test
Follow-up
Participants are monitored for safety and effectiveness after dietary intervention
What Are the Treatments Tested in This Trial?
Interventions
- Hypercaloric, High Fat Diet
Trial Overview
The study tests how a high-fat diet over three days affects the body's response to sugar and insulin during an oral glucose tolerance test. Participants will undergo metabolic measurements before and after the diet to see how reduced insulin sensitivity impacts metabolism.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
For three calendar days participants will be asked to track all foods they eat and beverages they drink (habitual diet) in a mobile application. Following the three days following the habitual diet, participants will consume 165% of their estimated daily energy needs with 65% of those calories coming from fat.
Find a Clinic Near You
Who Is Running the Clinical Trial?
George Washington University
Lead Sponsor
Citations
Consumption of a High-Fat Diet Induces Central Insulin ...
These data support the conclusion that, in the presence of a HF diet, insulin is less effective. The LF and chow diets employed have comparable low fat content, ...
Effects of a Hypercaloric and Hypocaloric Diet on Insulin ...
The hypercaloric diet increased body weight (3.5 kg; P<0.001) and fat percentage (3.5%; P<0.001) but did not affect glucose uptake nor lipolysis ...
Thirty days of combined consumption of a high-fat diet and ...
Thirty days of combined consumption of a high-fat diet and fructose-rich beverages promotes insulin resistance and modulates inflammatory response and ...
Distinct Influence of Hypercaloric Diets Predominant with ...
Overfeeding of a hypercaloric diet leads to obesity, diabetes, chronic inflammation, and fatty liver disease. Although limiting fat or carbohydrate intake ...
Short-term high-fat and high-carb diet effects on glucose ...
Participants preferred high-fat milk, dairy products, and fats over low-fat options. 79% of participants consumed meat one or several times per week, and again, ...
Evaluating the Impact of Different Hypercaloric Diets on ...
The present investigation evaluates the impact of different hypercaloric diets and different times of exposure to diets on weight gain, insulin resistance, ...
Diet, Insulin Resistance, and Obesity: Zoning in on Data for ...
These high-fat diets have been shown to be safe in the short term; however, their long-term safety has not been established. With respect to insulin ...
The role of dietary fat in obesity-induced insulin resistance
However, despite a similar body weight, obese high-fat diet-fed mice are more insulin resistant than mice fed an isocaloric low-fat diet.
Diets High in Protein or Saturated Fat Do Not Affect Insulin ...
Our data support the evidence that high SF intake does not have a major impact on insulin sensitivity. Measures of biomarkers of SF and protein intake suggest ...
A high-fat, high-saturated fat diet decreases insulin sensitivity ...
A diet very high in fat and saturated fat adversely affects insulin sensitivity and thereby might contribute to the development of type 2 diabetes.
Other People Viewed
By Subject
By Trial
Related Searches
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.