Healthy Eating for Aging

Overseen By Courtney Peterson, Ph.D.

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Pennington Biomedical Research Center

Must not be taking: Chronic condition medications

Disqualifiers: Diabetes, Hypertension, Cancer, others

Compensation: Varies

Number of Visits: Unknown

Duration: 24 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores various methods to change eating habits and potentially slow aging. It tests five approaches, including calorie restriction (eating fewer calories) and time-restricted eating (eating only during certain hours). The trial seeks healthy young adults without obesity who have maintained a stable body weight over the past six months. Participants should regularly wake up between 5-8 AM and have no major health problems. As an unphased trial, this study offers a chance to contribute to groundbreaking research on lifestyle changes that may promote healthier aging.

Will I have to stop taking my current medications?

The trial excludes individuals who regularly use medications for chronic medical conditions, so you would need to stop taking such medications to participate.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that reducing calories is generally safe for people. One study found that cutting calorie intake for two years improved health and was manageable for participants without serious side effects. Other research suggests that eating fewer calories can extend lifespan and delay age-related diseases across different species.

For time-restricted eating (TRE), studies indicate it is safe and popular among participants. Trials where people ate only during a 6 to 10-hour window resulted in weight loss and improved health without major issues. Both traditional and flexible TRE methods have demonstrated similar benefits, with participants losing weight and maintaining health improvements over time.

Overall, studies have shown that both calorie restriction and time-restricted eating are safe and beneficial. Participants usually manage these dietary changes well. ^{1 2 3 4 5}

Why are researchers excited about this trial's treatments?

Researchers are excited about the Healthy Eating for Aging trial because it explores innovative ways to implement calorie restriction (CR) and time-restricted eating (TRE) for aging health. Unlike traditional methods that require in-person sessions, the trial includes adaptive CR and TRE options delivered remotely using technology, making these interventions more accessible and flexible for participants. This approach could lead to more personalized and sustainable dietary changes, potentially enhancing adherence and effectiveness in promoting healthy aging. Additionally, the trial compares these adaptive methods with traditional in-person and control groups, offering valuable insights into the most effective strategies for dietary interventions.

What evidence suggests that this trial's dietary interventions could be effective for slowing aging?

This trial will compare different approaches to calorie restriction (CR) and time-restricted eating (TRE) to assess their effects on aging and health. Traditional CR, one study arm, involves eating about 25% less than usual and has improved signs of aging and potentially extended lifespan in studies. Adaptive CR, another arm in this trial, uses technology to assist with calorie reduction and shows promise for slowing aging.

Time-restricted eating (TRE) is another method under study, where participants eat only during an 8-hour period each day. Research indicates that TRE can help reduce body fat and improve health without muscle loss. The trial will also evaluate Adaptive TRE, which incorporates technology to support healthy aging and improve health markers. Both CR and TRE, as studied in this trial, have the potential to slow aging and boost overall health. ^{6 7 8 9 10}

Are You a Good Fit for This Trial?

The DiAL Health Research Study is for healthy individuals aged 25-45 with a BMI between 22 and below 30, who have maintained a stable weight recently, wake up early, and don't use chronic medications. Excluded are those with serious health conditions, pregnant or lactating women, heavy smokers or drinkers, extreme athletes, and people with unconventional eating habits.

Inclusion Criteria

Your body mass index (BMI) is between 22 and 30, which is considered a healthy weight range.

Stable body weight (less than ± 2kg) in the past 6 months

Regularly wake up between 5-8 AM

Exclusion Criteria

Depression as determined by the Beck Depression Inventory-II > 19

Pregnant, postpartum (< 12 months) or lactating females or attempting to become pregnant in the next 7 months

My bone density test shows a score lower than -2.0 in my hip or spine.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are randomized to one of five dietary intervention groups: ad libitum Control, Traditional CR, Adaptive CR, Traditional TRE, or Adaptive TRE for 24 weeks

24 weeks

Regular in-person or remote sessions depending on the group

Follow-up

Participants are monitored for adherence and satisfaction with the intervention

6 months

What Are the Treatments Tested in This Trial?

Interventions

• DiAL Health Research Study

Trial Overview This study tests the effectiveness of different dietary interventions aimed at slowing aging processes in young adults without obesity. It's a pilot trial with five groups to see which diet might help improve treatment compliance and support weight loss while promoting healthier aging.

How Is the Trial Designed?

Group I: Traditional CR Active Control 1 Intervention

A 25% calorie restriction (CR) intervention delivered via traditional in-person sessions.

Group II: Adaptive CR Active Control 1 Intervention

A 25% calorie restriction (CR) intervention delivered via a remote, adaptive, and technology-driven intervention program.

Group III: Traditional TRE Active Control 1 Intervention

An eight-hour time restricted eating (TRE) intervention delivered via traditional in-person sessions.

Group IV: Adaptive TRE Active Control 1 Intervention

An eight-hour time restricted eating (TRE) intervention delivered via a remote, adaptive, and technology driven intervention program.

Group V: ad libitum Control Placebo Group 1 Intervention

No treatment control condition.

Who Is Running the Clinical Trial?

Pennington Biomedical Research Center

Lead Sponsor

Trials

314

Recruited

183,000+

Citations

1. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/40454302/

Intervening on Calorie Intake or Eating Timing in Older Adults The Healthy Aging and Late Life Outcomes Pilot (HALLO-P) trial was designed to pilot in-person and remotely delivered caloric restriction (CR and RCR ...

2. clinicaltrials.gov clinicaltrials.gov/study/NCT05549362

Study Details | NCT05549362 | DiAL Health Research Study Continuous calorie restriction (CR), the most studied intervention, extends lifespan in animals and, in humans, slows biological aging and improves healthspan ( ...

3. reporter.nih.gov reporter.nih.gov/search/JbRgAtchAUKHOoW2X1vObQ/project-details/10697324

martin, corby k PROJECT NARRATIVE Continuous calorie restriction (CR) slows biological aging and improves healthspan, but, in earlier interventions, adherence to CR ...

4. researchgate.net researchgate.net/publication/392068920_Intervening_on_Calorie_Intake_or_Eating_Timing_in_Older_Adults_Lessons_Learned_in_the_Healthy_Aging_and_Late-Life_Outcomes_Randomized_Controlled_Pilot_Trial

Intervening on Calorie Intake or Eating Timing in Older Adults Purpose The Healthy Aging and Late Life Outcomes Pilot (HALLO-P) trial was designed to pilot in-person and remotely delivered caloric ...

5. sciencedirect.com sciencedirect.com/science/article/am/pii/S0531556522000651

Results from CALERIE™ 2 A sample weight graph is displayed for a hypothetical participant in the. Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIETM).

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC3185196/

The CALERIE Study: Design and methods of an innovative 25 ... The study was undertaken to examine 2 years of sustained CR on: a) slowing aging as assessed by proxy indicators and b) protecting against age-related disease ...

7. sciencedirect.com sciencedirect.com/science/article/abs/pii/S0531556522000651

Challenges in defining successful adherence to calorie ... The results highlight the challenges of: 1) setting a single CR goal vs. a range of acceptable values, and 2) obtaining real-time and valid measures of CR ...

8. nejm.org nejm.org/doi/full/10.1056/NEJMoa2114833

Calorie Restriction with or without Time-Restricted Eating ... Several pilot clinical studies showed that time-restricted eating resulted in reduction over time in the body weight and fat mass in patients ...

9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11485046/

Clinical Insights on Caloric Restriction Mimetics for Mitigating ... To maneuver around cumbersome diets, Caloric Restriction Mimetics (CRMs) have emerged as promising alternatives by mimicking the beneficial effects of CR. This ...

10. embopress.org embopress.org/doi/10.15252/emmm.202114418

The ups and downs of caloric restriction and fasting In non‐obese adults, ADF can result in CR of around 35%, as the calorie loss is not fully compensated on eating days (Stekovic et al, 2019). ADF ...