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Nanopore Sequencing for Pancreatic Cancer Detection

Phase < 1

Waitlist Available

Led By Nicholas D Chia

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

>= 18 year (yr) male (M) or female (F)

Undergoing pancreaticoduodenectomy or total pancreatectomy for any benign or malignant indication with informed consent

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 2 years

Awards & highlights

Study Summary

This trial is testing if nanopore sequencing can help detect bacteria that leads to surgical site infections in patients with pancreatic tumors.

Who is the study for?

This trial is for adults over 18 who are having surgery (pancreaticoduodenectomy or total pancreatectomy) for any pancreatic tumor, benign or cancerous. It's not open to pregnant women, those in institutions like prisons, people unable to consent, patients needing emergency surgery, or anyone already in a similar antibiotic study.Check my eligibility

What is being tested?

The trial is testing nanopore sequencing—a rapid lab method—to detect bacteria in bile during pancreatic tumor surgeries. The goal is to see if this can prevent or improve treatment of surgical site infections by identifying harmful bacteria quickly.See study design

What are the potential side effects?

Since the interventions involve diagnostic procedures rather than medications, typical drug side effects aren't expected. However, there may be risks associated with collecting biospecimens and potential discomfort from the laboratory procedure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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I am scheduled for surgery on my pancreas with consent.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Improved antibiotic stewardship

Reduction in surgical site infections

Secondary outcome measures

Cost effectiveness (reduced total hospital costs)

Timeliness of sample analysis

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Arm II (biospecimen, nanopore sequencing, routine testing)Experimental Treatment3 Interventions

Patients undergo the collection of bile samples during standard of care surgery. Samples undergo nanopore sequencing and routine laboratory testing.

Group II: Arm I (biospecimen collection, routine testing)Active Control2 Interventions

Patients undergo the collection of bile samples during standard of care surgery. Samples undergo routine laboratory testing.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Biospecimen Collection

2004

Completed Phase 2

~1730

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH

13,654 Previous Clinical Trials

40,933,145 Total Patients Enrolled

Mayo ClinicLead Sponsor

3,205 Previous Clinical Trials

3,766,776 Total Patients Enrolled

Nicholas D ChiaPrincipal InvestigatorMayo Clinic in Rochester

Media Library

Laboratory Procedure Clinical Trial Eligibility Overview. Trial Name: NCT05523154 — Phase < 1

Pancreatic Cancer Research Study Groups: Arm II (biospecimen, nanopore sequencing, routine testing), Arm I (biospecimen collection, routine testing)

Pancreatic Cancer Clinical Trial 2023: Laboratory Procedure Highlights & Side Effects. Trial Name: NCT05523154 — Phase < 1

Laboratory Procedure 2023 Treatment Timeline for Medical Study. Trial Name: NCT05523154 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies available for prospective participants of this medical experiment?

"As indicated by clinicaltrials.gov, this medical study is no longer recruiting patients; it was initially posted on December 15th 2022 and the most recent revision took place November 29th 2022. Nevertheless, there are still a large number of other trials looking for volunteers at present with 2,901 studies available to join."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

"Answers in Hours" A Randomized Controlled Trial Using Microbiome Metagenomics for Bile Duct Cultures

2023. ""Answers in Hours" A Randomized Controlled Trial Using Microbiome Metagenomics for Bile Duct Cultures". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05523154.

All > Microbiome