Aspirin for Sleep Deprivation-Related Inflammation
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how aspirin affects inflammation related to sleep deprivation. It examines the pattern where people restrict sleep during the week and try to catch up over the weekend. Researchers aim to determine if aspirin can resolve inflammation caused by this sleep pattern. Participants may receive either aspirin or a placebo (a pill with no active ingredient) to compare effects. Ideal candidates should maintain a regular sleep schedule of 7-9 hours nightly and have no history of asthma or chronic health issues. As an Early Phase 1 trial, this research focuses on understanding how aspirin works in people, offering participants a chance to contribute to groundbreaking insights.
Will I have to stop taking my current medications?
Yes, you will need to stop taking regular medications, except for oral contraceptives, to participate in this trial. Additionally, you should not have taken NSAIDs or cold/cough remedies in the last month, or dietary supplements with DHA/EPA-derived fatty acids in the last three months.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that low-dose aspirin is generally well-tolerated and can help reduce inflammation caused by insufficient sleep. In various studies, participants who took low-dose aspirin experienced less inflammation than those who took a placebo, a pill with no active ingredients. This suggests that aspirin might safely manage inflammation from lack of sleep. Additionally, low-dose aspirin is already widely used and approved for other health issues, supporting its safety. However, since this trial is in its early stages, researchers are still learning about its safety for this specific use.12345
Why are researchers excited about this trial's treatments?
Most treatments for sleep deprivation-related inflammation involve lifestyle changes, like improving sleep habits, or medications targeting inflammation directly. However, this trial is exploring the use of aspirin, a common anti-inflammatory medication, as a potential treatment. Researchers are excited about this approach because aspirin is well-known, widely available, and generally safe at low doses. The trial aims to uncover if a low-dose aspirin regimen can reduce inflammation caused by sleep deprivation, offering a simple and cost-effective solution compared to current options. If successful, this could provide an easily accessible treatment option for people struggling with sleep-related inflammation issues.
What evidence suggests that aspirin might be an effective treatment for sleep deprivation-related inflammation?
Research has shown that low-dose aspirin can reduce inflammation caused by insufficient sleep. In this trial, participants will join different arms to evaluate the effects of aspirin versus a placebo. Studies have found that taking aspirin before anticipated sleep loss can lower the body's inflammatory response. This suggests aspirin might help manage inflammation often associated with sleep deprivation. Specifically, findings indicate that, compared to a placebo, aspirin effectively reduced markers of inflammation in the body during sleep deprivation. These results suggest aspirin could benefit those dealing with inflammation related to lack of sleep.14678
Who Is on the Research Team?
Monika Haack, PhD
Principal Investigator
Beth Israel Deaconess Medical Center
Are You a Good Fit for This Trial?
Adults aged 18-65 with a regular sleep pattern of 7-9 hours, starting around 11:00pm, and no significant pre-menstrual discomfort can join. They must not have asthma, high blood pressure, gastrointestinal issues, stroke history, NSAID allergies or intolerance, certain sleep disorders, be pregnant/nursing or taking specific supplements. A clean toxicology screen and BMI between 18.5-35 are required.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-treatment
Participants take a daily pill (placebo or 81mg aspirin) at bedtime over a 2-week period prior to the in-hospital stay
In-hospital Treatment
Participants undergo three 11-day in-hospital stays with control sleep or sleep restriction-recovery patterns, combined with continued daily pill intake
Follow-up
Participants are monitored for changes in inflammatory markers after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Aspirin
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
Beth Israel Deaconess Medical Center
Lead Sponsor