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Diuretic

Antihypertensive drug treatment Arm for High Blood Pressure

Q: Would it be possible for me to participate in this medical study?

To qualify for enrollment in this research study, individuals must exhibit <a href="https://www.withpower.com/clinical-trials/hypertension">hypertension</a> and fall between the ages of 60 to 85. The trial aims to recruit a cohort of 50 participants.

Q: Are participants currently being recruited for this study?

The clinical trial listed on clinicaltrials.gov is no longer open for participant recruitment. It was first posted on April 1st, 2024 and last updated on February 23rd, 2024. Despite this study being closed to enrollment, there are currently 754 other trials actively seeking participants.

Q: Is there an age restriction for participation in this research trial, particularly concerning individuals under the age of 30?

To be considered for this research study, candidates must fall within the age range of 60 to 85. Notably, there are a total of 46 trials targeting individuals below 18 years old and 677 studies focusing on participants above 65 years old.

Phase < 1

Waitlist Available

Led By TAKURO WASHIO, Ph.D.

Research Sponsored by University of Texas Southwestern Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 2 weeks post intervention

Awards & highlights

Study Summary

This trial aims to study the effects of drug treatment for high blood pressure on brain health in older adults. The researchers will recruit participants with high blood pressure and give them either the drug treatment or a placebo

Who is the study for?

This trial is for older adults with high blood pressure who have not yet started treatment. Participants should be generally healthy, without conditions that could interfere with the study or pose additional risks.Check my eligibility

What is being tested?

The study tests if chlorthalidone (a drug for high blood pressure) affects brain blood flow and cognitive function compared to a placebo over two weeks. Researchers will monitor changes in participants' brain health and nervous system regulation.See study design

What are the potential side effects?

Potential side effects of chlorthalidone may include dizziness, dehydration, electrolyte imbalance, and possible impact on kidney function. Placebo has no active ingredients but can cause perceived side effects due to the 'placebo effect.'

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 2 weeks post intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 2 weeks post intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 2 weeks post intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Cerebral blood flow from baseline at 2 weeks post intervention

Change in Muscle sympathetic nerve activity (MSNA) from baseline at 2 weeks post intervention

Change in cognitive performance from baseline at 2 weeks post intervention via NIH Toolbox Cognitive Battery

+1 more

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Antihypertensive drug treatment ArmActive Control1 Intervention

Participants will take a fixed dose of chlorthalidone (a diuretic, 25 mg orally once daily) for two week, with study visits for laboratory assessment at before and after intervention.

Group II: Placebo treatment ArmPlacebo Group1 Intervention

Participants will receive placebo treatment for two weeks, with study visits for laboratory assessment at before and after intervention.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor

1,050 Previous Clinical Trials

1,054,309 Total Patients Enrolled

TAKURO WASHIO, Ph.D.Principal InvestigatorUT Southwestern Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Would it be possible for me to participate in this medical study?

"To qualify for enrollment in this research study, individuals must exhibit hypertension and fall between the ages of 60 to 85. The trial aims to recruit a cohort of 50 participants."

Answered by AI

Are participants currently being recruited for this study?

"The clinical trial listed on clinicaltrials.gov is no longer open for participant recruitment. It was first posted on April 1st, 2024 and last updated on February 23rd, 2024. Despite this study being closed to enrollment, there are currently 754 other trials actively seeking participants."

Answered by AI

Is there an age restriction for participation in this research trial, particularly concerning individuals under the age of 30?

"To be considered for this research study, candidates must fall within the age range of 60 to 85. Notably, there are a total of 46 trials targeting individuals below 18 years old and 677 studies focusing on participants above 65 years old."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension.

Takuro Washio 2024. "Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension.". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06287580.