DBS Parameter Optimization for Epilepsy
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of this treatment for epilepsy?
Deep brain stimulation (DBS) has shown promise in reducing seizures for people with epilepsy who do not respond to medication. Studies have demonstrated that DBS can modulate brain circuits and decrease the abnormal brain activity associated with seizures, leading to a reduction in seizure frequency.12345
Is deep brain stimulation (DBS) generally safe for humans?
How is the DBS treatment for epilepsy different from other treatments?
Deep Brain Stimulation (DBS) for epilepsy is unique because it involves implanting a device that sends electrical impulses to specific brain areas to reduce seizures, especially in patients who do not respond to medications. Unlike traditional treatments, DBS can be adjusted in real-time to optimize its effects, and it offers a reversible and minimally invasive option for managing epilepsy.145910
What is the purpose of this trial?
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.
Research Team
Robert McGovern, MD
Principal Investigator
University of Minnesota
Eligibility Criteria
This trial is for patients with epilepsy that doesn't respond to medication and who already have a deep brain stimulator implanted. It's not suitable for individuals with severe dementia as determined by the study investigator.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive deep brain stimulation with optimized parameters based on power spectral density measures
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Implantable Neural Stimulators (INSs)
Implantable Neural Stimulators (INSs) is already approved in United States, European Union for the following indications:
- Focal-onset seizures with or without focal to bilateral seizures in adults who have not responded to three or more antiseizure medications
- Epilepsy in adults with focal-onset seizures who have not achieved adequate seizure control despite appropriate trials of antiepileptic medication
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Minnesota
Lead Sponsor