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Hormone Therapy for Cardiovascular Health in Breast Cancer Patients (CROWN Trial)
CROWN Trial Summary
This trial is testing whether breast cancer patients' hearts change when they go on a specific type of hormone therapy.
CROWN Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowCROWN Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.CROWN Trial Design
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Who is running the clinical trial?
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- You are allergic to gadolinium or other contrast agents.I do not have any severe illnesses or social situations that would stop me from following the study's requirements.I am starting or have started breast cancer treatment with hormone therapy after menopause induction.I am experiencing heart symptoms that need urgent investigation.I am being treated with SERD instead of an aromatase inhibitor.I had COVID-19 but have recovered, except for possible loss of taste/smell or mild fatigue.I have had heart artery treatment in the last 6 months or have severe heart artery disease that can't be treated with surgery.I have other cancers, but they're not expected to affect my heart.I am currently or have been treated with specific targeted therapies for cancer.I have long-term kidney problems or abnormal blood salt levels.I am a man diagnosed with breast cancer.You have certain metal devices in your body that make it unsafe for you to have an MRI.I am able to care for myself and perform daily activities.I have asthma or COPD and need medication for it.You have had allergic reactions to drugs that are similar to adenosine.I am a woman 55 or younger and was premenopausal when diagnosed with breast cancer.I have been diagnosed with early to locally advanced breast cancer.My breast cancer is either HER2 positive or negative.
- Group 1: Near-Complete Estrogen Deprivation Therapy Participants
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the scope of participants in this research endeavor?
"Affirmative. Records from clinicaltrials.gov verify that this research study, which was posted on September 2nd 2022, is currently recruiting participants. Approximately 90 individuals need to be enrolled at 3 different medical centres."
Is recruitment for this research endeavor still open?
"Affirmative. According to the information on clinicaltrials.gov, this medical trial is currently recruiting candidates and was first posted on September 2nd 2022 before being updated most recently on October 7th 2022. 90 individuals from 3 sites are needed for full participation in the experiment."
Is it possible to take part in this research project?
"This medical trial seeks to recruit 90 individuals aged between 18 and 55 who were diagnosed with breast cancer. To partake, they must adhere the following conditions: NCED treatment plan complete with aromatase inhibitor or SERD therapy post-chemotherapy/surgery/radiation; no higher than ECOG 2; serum potassium level of 3.5 – 5.2 mmol/L and eGFR >30ml per min per 1.73m2; age ≤55 at diagnosis time (premenopausal); HER2 positive tumour admissible; concurrent malignancies permissible if not impacting cardiovascular activity; prior COVID-19"
Are adults aged 30 or older allowed to participate in this experiment?
"Prospective participants must be aged 18-55. There are 75 trials for minors and 2576 studies open to seniors."
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