Chest CT Scan for Lung Cancer
(IDEAL Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to find better ways to screen for lung cancer and manage lung nodules (small growths in the lung). Researchers seek to identify high-risk individuals who might benefit from a special type of CT scan (chest CT scan) but aren't currently eligible. They are also developing a simple test using breath and blood samples to detect cancer and determine if lung nodules are cancerous. The study seeks participants with a lung nodule of at least 6mm, who haven't smoked in the last 24 hours, and can provide a breath sample. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could improve early detection and management of lung cancer.
Do I need to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It seems likely that you can continue them, but you should confirm with the trial organizers.
What prior data suggests that this method is safe for lung cancer screening?
Research has shown that chest CT scans are safe for detecting lung issues. These scans often reveal small growths in the lungs called pulmonary nodules, with more than 95% being non-cancerous and usually not harmful.
Chest CT scans are non-invasive, similar to an X-ray, and do not require surgery. They use a small amount of radiation to capture images of the lungs, and this radiation level is generally considered safe. Doctors adhere to guidelines to monitor any nodules found, ensuring proper management.
Overall, chest CT scans are well-tolerated and have a strong safety record in patients.12345Why are researchers excited about this trial?
Researchers are excited about using chest CT scans for lung cancer detection because they provide detailed images that can spot small nodules in the lungs, which might go unnoticed with traditional X-rays. Unlike other methods that might require invasive procedures for a clear diagnosis, CT scans are non-invasive and offer a faster, more comfortable experience for patients. This approach could lead to earlier detection and treatment of lung cancer, potentially improving outcomes and survival rates.
What evidence suggests that a Chest CT Scan is effective for identifying lung cancer?
Studies have shown that chest CT scans effectively detect early-stage lung cancer. Research indicates that a computerized system for tracking lung nodules can increase the detection of stage 1 non-small cell lung cancer (NSCLC) when examining unexpected lung nodules. One study found that even with a very low-dose CT scan, the nodule detection rate remained high at 84.6%. This suggests that chest CT scans are a powerful tool for early lung cancer detection, which is crucial for better outcomes. Although not all nodules are cancerous, these scans assist doctors in determining the best next steps. Participants in this trial will join the Incidental Pulmonary Nodule Arm, where nodule follow-up will adhere to Fleischner Guidelines.678910
Who Is on the Research Team?
Renelle L Myers, MD
Principal Investigator
VCH, UBC
Rayjean Hung, PhD
Principal Investigator
Sinai Health
Are You a Good Fit for This Trial?
The IDEAL Study is for people at high risk of lung cancer who don't currently qualify for low-dose CT (LDCT) screening. It's also for those with Incidental Pulmonary Nodules (IPNs). Participants should be willing to provide detailed personal health information, a breath sample, and a small blood sample.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Breath and Blood Sample Collection
Participants provide a breath sample and 1-2 tablespoons of blood for analysis
CT Scan Review and Follow-up
CT scans with IPNs are reviewed and followed up as per current clinical guidelines
Follow-up
Participants are monitored for safety and effectiveness after initial assessments
What Are the Treatments Tested in This Trial?
Interventions
- Chest CT Scan
Trial Overview
This study tests methods to improve early lung cancer detection in diverse populations. It evaluates the use of Chest CT scans to manage IPNs and develops new tests using breath and blood samples to distinguish between cancerous and non-cancerous nodules.
How Is the Trial Designed?
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Treatment groups
Experimental Treatment
Nodule Follow up as per Fleischner Guidelines
Find a Clinic Near You
Who Is Running the Clinical Trial?
British Columbia Cancer Agency
Lead Sponsor
Laval University
Collaborator
Lunenfeld Tanenbaum Research Institute
Collaborator
Canadian Cancer Society (CCS)
Collaborator
University Health Network, Toronto
Collaborator
Lunenfeld Tanenbaum Research Institute
Collaborator
Citations
Management and Outcomes of Pulmonary Nodules in a ...
CT-guided biopsy was performed in 10 patients as first step. In 60% (6/10), histology revealed lung cancer, and in 40% (4/10), benign results ...
Interventions to Improve Adherence to Clinical Guidelines for ...
Lung cancer survival has only modestly improved over time, and long-term survival remains poor (10% 10-year survival rate) with a key driver of ...
Data-driven risk stratification and precision management of ...
For instance, only 3.6% of detected lung nodules were diagnosed as malignant in the NLST, and the baseline false-positive rate (FPR) was as high ...
Improvement in Stage of Lung Cancer Diagnosis With ...
The application of a patient tracking system and computerized lung nodule registry lead to an increased frequency in the diagnosis of stage 1 NSCLC from IPNs.
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insightsimaging.springeropen.com
insightsimaging.springeropen.com/articles/10.1186/s13244-024-01888-1Ultra-low dose dual-layer detector spectral CT for ...
These results were confirmed by quantitative image quality analysis with a favorable nodule detection rate of 84.6% for EDM at ultra-low dose CT ...
Incidental Pulmonary Nodules: Differential Diagnosis and ...
More than 95% of all pulmonary nodules revealed by computerized tomography (CT) are benign, but many cases are not managed in conformity with the guidelines. In ...
Creating an Incidental Pulmonary Nodule Safety-Net ...
Incidental pulmonary nodules on CT scans have been reported in 2.5% to 8.4% of abdominal CT scans,4, 5, 6, 7, 8 in 10% to 30% of chest CT scans,9, 10, 11, 12, ...
Pulmonary Nodules | Cancer Screening, Prevention, Control
Approximately 50% of patients who undergo CT screening for lung cancer are found to have a pulmonary nodule. Approximately 95% of pulmonary ...
INCIDENTAL LUNG NODULE PROGRAM: A NEW ...
Our ILN program serves as a vital healthcare safety net, detecting and monitoring potentially malignant nodules.
Pulmonary Nodules: Common Questions and Answers
The incidence of pulmonary nodules in lung cancer screening programs has been reported at approximately 27%, with 1.1% of patients diagnosed with lung cancer.
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