Caffeine for Learning in Healthy Adults
(Caffeine-RAC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how caffeine affects learning compared to a placebo. Researchers aim to understand how caffeine influences the brain's reward signals and activities during learning tasks. Participants will engage in tasks while undergoing brain scans to track these changes. The trial seeks healthy adults who regularly consume caffeine (between 100 mg and 450 mg daily) and do not smoke. As a Phase 4 trial, this research helps clarify how caffeine, an already FDA-approved and effective substance, benefits more patients.
Will I have to stop taking my current medications?
Yes, if you are on chronic medications like painkillers or steroids, you would need to stop taking them to participate in this trial.
What is the safety track record for caffeine?
Research has shown that caffeine is generally safe for most people when consumed in moderate amounts. One study found that about 3 milligrams of caffeine per kilogram of body weight is safe, significantly lower than the dangerous level of 80–100 milligrams per kilogram, which could be deadly. Another study indicated that caffeine can be part of a healthy diet, though excessive consumption can be risky.
While most people tolerate caffeine well, some may experience jitteriness, sleep disturbances, or an upset stomach. These effects are usually mild and subside when caffeine intake is reduced or stopped. Overall, caffeine is widely used and considered safe in reasonable amounts.12345Why are researchers enthusiastic about this study treatment?
Unlike the standard of care for boosting learning and memory, which often involves complex nootropic supplements or prescription medications, caffeine is a simple, widely available compound with a long history of use. Researchers are excited about caffeine because it works by blocking adenosine receptors in the brain, which can enhance alertness and cognitive performance. The study is also examining a straightforward delivery method—a 200mg caffeine tablet—making it easy to administer and potentially more accessible than other cognitive enhancers. This approach could offer a quick and effective boost to learning capabilities in healthy adults without the need for more elaborate treatments.
What evidence suggests that caffeine might be an effective treatment for learning?
Research shows that caffeine can improve brain function. Several studies have found that caffeine boosts memory, attention, and reaction times. For instance, one study with 9,003 adults found a connection between regular caffeine consumption and better verbal memory. Other research indicates that even small amounts of caffeine can enhance learning and mood. In this trial, participants will receive either a caffeine tablet or a placebo. Overall, caffeine appears to positively affect the brain, suggesting it might enhance learning through feedback and rewards.15678
Are You a Good Fit for This Trial?
This trial is for healthy adults interested in how caffeine affects learning. Participants will do tasks during a brain scan to see changes in dopamine, which helps with reward signals. They must be eligible based on certain health criteria not specified here.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Washout
Participants undergo a 6-day ambulatory washout period abstaining from caffeine, alcohol, and drugs
Treatment
Participants receive either caffeine or placebo and undergo PET/fMRI scans to assess neurochemical and hemodynamic changes
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Caffeine
Trial Overview
The study tests the effects of a 200 mg caffeine dose versus a placebo on reinforcement learning and motor inhibition using advanced PET/MRI brain imaging to track dopamine levels and brain activity during cognitive tasks.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Caffeine tablet, 200mg
Lactose tablet
Find a Clinic Near You
Who Is Running the Clinical Trial?
Hsiao-Ying Wey
Lead Sponsor
Citations
Effects of Caffeine on Cognitive Performance, Mood ... - NCBI
In summary, studies indicate that caffeine can have significant effects on mood and performance, even at relatively low doses, in non-sleep-deprived individuals ...
A review of caffeine's effects on cognitive, physical and ...
Nevertheless, a study of 9003 adults by Jarvis (1993) found a positive relationship between habitual caffeine consumption and performance on verbal memory, ...
Drinking coffee enhances neurocognitive function by ...
Some studies have shown beneficial effects of caffeine on cognitive functioning, including reaction times to cognitive tasks, attention, working ...
Exploring the impact of coffee consumption and caffeine ...
This study provides evidence of a positive correlation between coffee consumption, caffeine intake, and cognitive performance in older adults.
Ad libitum caffeine consumption, cognitive performance ...
Research has shown that controlled doses of caffeine can enhance cognitive function, including vigilance, learning, memory, and mood state, even ...
Caffeine intake and Cognitive Functions in Children - PMC
The results obtained from this study indicated that increasing caffeine intake was associated with lower scores in several cognitive functions, such as ...
Caffeine supplementation improves the cognitive abilities ...
Ingestion of 5 g (80–100 mg/kg) is likely to prove fatal. Therefore, caffeine with 3 mg/kg is a safe psychomotor-activating supplementation for ...
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ama-assn.org
ama-assn.org/public-health/prevention-wellness/what-doctors-wish-patients-knew-about-impact-caffeineWhat doctors wish patients knew about the impact of caffeine
Caffeine can be part of a healthy diet for most people, but too much may pose a danger to your health. Four physicians share what to keep in mind.
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