Brain Stimulation for Negative Emotions
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial investigates whether a non-invasive technique called transcranial temporal interference stimulation (tTIS) can reduce negative emotions. It also examines how care providers' expectations might influence the treatment's effectiveness. Participants will receive either active or inactive tTIS and hear either positive or negative messaging about the treatment's potential benefits. This study suits individuals without psychiatric diagnoses, seizure disorders, or severe migraines who are comfortable with the trial's tasks and procedures. As an unphased trial, it offers participants the chance to contribute to groundbreaking research in emotional regulation techniques.
Will I have to stop taking my current medications?
Yes, you will need to stop taking any medications that affect the central nervous system or are used for neurological or psychiatric treatment to participate in this trial.
What prior data suggests that transcranial temporal interference stimulation (tTIS) is safe for reducing negative emotions?
Research has shown that transcranial temporal interference stimulation (tTIS) is generally safe and well-tolerated in people. One study found that tTIS can be used at certain electricity levels without causing harm, allowing it to safely reach deep brain areas through electrical currents applied to the scalp.
Another study confirmed that tTIS is safe for humans and can target specific brain areas, such as the hippocampus, without causing major side effects. Participants reported few, if any, negative reactions during these trials.
While researchers continue to study tTIS, current evidence suggests it is a low-risk option for brain stimulation.12345Why are researchers excited about this trial?
Researchers are excited about Transcranial Temporal Interference Stimulation (tTIS) because it offers a fresh approach to addressing negative emotions by using non-invasive brain stimulation. Unlike traditional treatments like medication or psychotherapy, tTIS uses precise electrical signals to target specific brain regions without the need for surgery or systemic drug exposure. This method is believed to minimize side effects and enhance treatment precision, potentially offering quicker and more effective relief from negative emotional states.
What evidence suggests that transcranial temporal interference stimulation (tTIS) might be an effective treatment for reducing negative emotions?
Research has shown that transcranial temporal interference stimulation (tTIS), which participants in this trial will receive, can reach deep brain areas without surgery. One study found that tTIS might help reduce depression symptoms in people with bipolar disorder. Another study suggested that tTIS could improve mental health by lowering negative emotions. These results are encouraging, but more research is needed to understand how effectively tTIS reduces negative feelings across different groups.16789
Are You a Good Fit for This Trial?
This trial is for individuals interested in exploring how brain stimulation and care provider expectations affect emotions. Participants will undergo non-invasive brain stimulation and receive messages about treatment effectiveness to measure changes in their emotional state.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Experiment 1
Participants complete four sessions with different combinations of active and sham tTIS and placebo messaging.
Experiment 2
Participants complete two sessions focusing on placebo manipulation effects with sham tTIS.
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Transcranial Temporal Interference Stimulation (tTIS)
Trial Overview
The study tests if transcranial temporal interference stimulation (tTIS) can lessen negative feelings, and whether positive or negative information from care providers alters this effect. It involves multiple sessions with different combinations of active/sham tTIS and placebo messaging.
How Is the Trial Designed?
6
Treatment groups
Experimental Treatment
Participants complete all two experimental sessions in the following sequence: 1. Session F; 2. Session E
Participants complete all two experimental sessions in the following sequence: 1. Session E; 2. Session F
Participants complete all four experimental sessions in the following sequence: 1. Session D; 2. Session A; 3. Session B; 4. Session C
Participants complete all four experimental sessions in the following sequence: 1. Session C; 2.Session D; 3. Session A; 4. Session B
Participants complete all four experimental sessions in the following sequence: 1. Session B; 2. Session C; 3. Session D; 4. Session A
Participants complete all four experimental sessions in the following sequence: 1. Session A; 2. Session B; 3. Session C; 4.Session D
Find a Clinic Near You
Who Is Running the Clinical Trial?
Trustees of Dartmouth College
Lead Sponsor
Citations
Individualized transcranial temporal interference stimulation ...
Secondary outcomes include changes in positive and negative symptoms, depressive and anxiety symptoms, sleep quality, quality of life, and ...
Efficacy and Safety of Transcranial Temporal Interference ...
Transcranial temporal interference stimulation (tTIS) has shown promise in targeting deep brain structures with minimal invasiveness. This study ...
Negative affective traits moderate transcranial direct ...
Taken together, our results suggest that the effects of tDCS on WM processes are influenced by the degree of interference arising from emotional ...
Effects of high-definition transcranial direct current ...
These results suggest that the DLPFC may reduce negative social emotional responses through implicit control during regulation. Furthermore ...
Transcranial magnetic stimulation and ... - PubMed Central
While Zhang and colleagues provided direct evidence that TMS and tDCS reduced negative emotions during down-regulation [43]. However, these ...
Recommendations for the Safe Application of Temporal ...
Temporal interference stimulation (TIS) is a new non-invasive brain stimulation method capable of targeting deep brain structures, unlike ...
Safety Recommendations for Temporal Interference ...
To this end, we sought to delineate a safe range of exposure parameters (voltages and currents applied via external scalp electrodes) for TIS in ...
Evaluation of tolerability and safety of transcranial electrical ...
Safety evaluation of employing temporal interference transcranial alternating current stimulation in human studies. Brain Sci. (2022) 12 ...
Non-invasive temporal interference electrical stimulation of ...
We demonstrate the safety and tolerability of TI stimulation in humans, the ability to focally target the stimulation locus to the hippocampus, ...
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