Samer S. Kasbari, MD, MS - Southeastern ...

Dr. Samer S. Kasbari

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Southeastern Medical Oncology Center-Clinton

Expert in Cancer
Expert in Breast cancer
72 reported clinical trials
132 drugs studied

Area of expertise

1

Cancer

Global Leader

Samer S. Kasbari has run 14 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage III
Stage I
2

Breast Cancer

Global Leader

Samer S. Kasbari has run 14 trials for Breast cancer. Some of their research focus areas include:

Stage IV
HER2 positive
ER positive

Affiliated Hospitals

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Southeastern Medical Oncology Center-Clinton

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Southeastern Medical Oncology Center-Goldsboro

Clinical Trials Samer S. Kasbari is currently running

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Chemotherapy + Immunotherapy

for Esophageal and Gastric Cancer

This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) for the treatment of advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, and gastric adenocarcinoma. The usual approach for patients is treatment with FOLFOX chemotherapy. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Fluorouracil stops cells from making DNA and it may kill tumor cells. Leucovorin is used with fluorouracil to enhance the effects of the drug. Oxaliplatin works by killing, stopping, or slowing the growth of tumor cells. Some patients also receive an immunotherapy drug, nivolumab, in addition to FOLFOX chemotherapy. Immunotherapy may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Irinotecan blocks certain enzymes needed for cell division and DNA repair, and it may kill tumor cells. Adding irinotecan to the FOLFOX regimen could shrink the cancer and extend the life of patients with advanced gastroesophageal cancers.

Recruiting

2 awards

Phase 3

2 criteria

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Osimertinib + Bevacizumab

for Lung Cancer

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.

Recruiting

2 awards

Phase 3

31 criteria

More about Samer S. Kasbari

Clinical Trial Related

6 years of experience running clinical trials · Led 72 trials as a Principal Investigator · 24 Active Clinical Trials

Treatments Samer S. Kasbari has experience with

  • Nivolumab
  • Carboplatin
  • Atezolizumab
  • Paclitaxel
  • Pembrolizumab
  • Cisplatin

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