Dr. Paul J. Hesketh
Claim this profileLahey Hospital and Medical Center
Studies Lung Cancer
Studies Non-Small Cell Lung Cancer
13 reported clinical trials
21 drugs studied
Area of expertise
1Lung Cancer
Stage III
Stage II
Stage IV
2Non-Small Cell Lung Cancer
Stage III
Stage II
Stage IV
Affiliated Hospitals
Clinical Trials Paul J. Hesketh is currently running
Osimertinib + Bevacizumab
for Lung Cancer
This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.
Recruiting2 awards Phase 331 criteria
Crizotinib
for Non-Small Cell Lung Cancer
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation.
Recruiting2 awards Phase 328 criteria
More about Paul J. Hesketh
Clinical Trial Related5 years of experience running clinical trials · Led 13 trials as a Principal Investigator · 6 Active Clinical TrialsTreatments Paul J. Hesketh has experience with
- Atezolizumab
- Pembrolizumab
- Biospecimen Collection
- Carboplatin
- Durvalumab
- Bevacizumab
Breakdown of trials Paul J. Hesketh has run
Lung Cancer
Non-Small Cell Lung Cancer
Lung Carcinoma
Anaplastic Large Cell Lymphoma
ALK Gene Rearrangement
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Paul J. Hesketh specialize in?
Paul J. Hesketh focuses on Lung Cancer and Non-Small Cell Lung Cancer. In particular, much of their work with Lung Cancer has involved Stage III patients, or patients who are Stage II.
Is Paul J. Hesketh currently recruiting for clinical trials?
Yes, Paul J. Hesketh is currently recruiting for 6 clinical trials in Burlington Massachusetts. If you're interested in participating, you should apply.
Are there any treatments that Paul J. Hesketh has studied deeply?
Yes, Paul J. Hesketh has studied treatments such as Atezolizumab, Pembrolizumab, Biospecimen Collection.
What is the best way to schedule an appointment with Paul J. Hesketh?
Apply for one of the trials that Paul J. Hesketh is conducting.
What is the office address of Paul J. Hesketh?
The office of Paul J. Hesketh is located at: Lahey Hospital and Medical Center, Burlington, Massachusetts 01805 United States. This is the address for their practice at the Lahey Hospital and Medical Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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