Emory Hope Clinic | Emory University ...

Dr. Nadine Rouphael, MD, MSc

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Hope Clinic

Studies Vaccine Response
Studies Healthy Subjects
7 reported clinical trials
12 drugs studied

Affiliated Hospitals

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Hope Clinic
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Emory University Hospital

Clinical Trials Nadine Rouphael, MD, MSc is currently running

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Flu Challenge Study

for undefined

This study examines how the immune system responds to the flu virus (H3N2) during and after infection and how the flu virus is transmitted in the environment. The study will used a flu virus called the H3N2 influenza challenge virus which was produced specifically for use in clinical research in controlled conditions. The study will also assess the safety of the H3N2 influenza challenge in healthy subjects. Mild to moderate symptoms are expected based on previous studies with this strain of influenza.
Recruiting1 award Phase 12 criteria
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Vaccines

for Durable Immune Response

The ability of the vaccines today to generate a long-lasting protection against infections varies greatly from one vaccine to another. The yellow fever vaccine (YF-17D) is one of the most successful vaccines ever developed, having been administered to over 600 million people globally. A single vaccination is known to induce durable protection over several decades. In contrast, the quadrivalent influenza vaccine (QIV) generates an immunity that wanes quickly with no long-lasting protection. Currently, the duration of immune protection for new vaccines is difficult to predict during vaccine product development and can only be ascertained by a "wait and see" approach. This is due, in part, to the fact that some of the signals that activate a durable immune system protection remain unknown. This study aims to provide a better understanding of this problem by vaccinating willing participants with either the FDA-approved yellow fever vaccine or the quadrivalent influenza vaccine and collecting baseline and follow-up biologic samples to compare how the immune system reacts.
Recruiting3 awards Phase 42 criteria

More about Nadine Rouphael, MD, MSc

Clinical Trial Related5 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 3 Active Clinical Trials
Treatments Nadine Rouphael, MD, MSc has experience with
  • Vaxchora
  • Shingrix®
  • SHINGRIX
  • Metronidazole
  • Neomycin Sulfate
  • Rabies Vaccine

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