Kimberley S. Mak, MD, MPH | Boston ...

Dr. Kimberley S. Mak

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Boston Medical Center

Studies Lung Cancer
Studies Non-Small Cell Lung Cancer
5 reported clinical trials
16 drugs studied

Area of expertise

1

Lung Cancer

Kimberley S. Mak has run 3 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage I
2

Non-Small Cell Lung Cancer

Kimberley S. Mak has run 2 trials for Non-Small Cell Lung Cancer. Some of their research focus areas include:

Stage IV
Stage I

Affiliated Hospitals

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Boston Medical Center

Clinical Trials Kimberley S. Mak is currently running

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Stereotactic Radiosurgery vs Whole-Brain Radiotherapy

for Brain Metastasis from Lung Cancer

This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Whole brain radiation therapy delivers a low dose of radiation to the entire brain including the normal brain tissue. Hippocampal avoidance during whole-brain radiation therapy (HA-WBRT) decreases the amount of radiation that is delivered to the hippocampus which is a brain structure that is important for memory. The drug, memantine, is also often given with whole brain radiotherapy because it may decrease the risk of side effects related to thinking and memory. Stereotactic radiosurgery may decrease side effects related to memory and thinking compared to standard of care HA-WBRT plus memantine.

Recruiting

2 awards

Phase 3

15 criteria

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MRI Monitoring vs. Preventive Brain Radiation

for Small Cell Lung Cancer

This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the actual spread of the cancer) may be at least as good as the combination of PCI with MRI scans.

Recruiting

2 awards

Phase 3

22 criteria

More about Kimberley S. Mak

Clinical Trial Related

4 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Kimberley S. Mak has experience with

  • Lung Surgery
  • SAbR
  • Docetaxel
  • Erlotinib Hydrochloride
  • Gemcitabine
  • Local Consolidation Therapy

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