Dr. Jodi L. Skiles
Claim this profileRiley Hospital for Children
Studies Adult T-Cell Leukemia/Lymphoma
Studies Acute Lymphoblastic Leukemia
7 reported clinical trials
11 drugs studied
Area of expertise
1Adult T-Cell Leukemia/Lymphoma
CD19 positive
CD22 positive
Stage II
2Acute Lymphoblastic Leukemia
CD19 positive
Stage II
Stage I
Affiliated Hospitals
Clinical Trials Jodi L. Skiles is currently running
Non-TBI Conditioning
for HCT in Acute Lymphoblastic Leukemia
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regimen as part of the treatment cohort of the study. Subjects who are pre-HCT NGS-MRD positive will be treated as per treating center standard and will be followed in an observational cohort (HCT center standard of care).
Recruiting1 award Phase 2
CAR T-Cell Therapy
for Leukemia and Lymphoma
Patients with relapsed or refractory leukemia or lymphoma are often refractory to further chemotherapy. In this study, the investigators will attempt to use T cells obtained directly from the patient, which can be genetically engineered to express a chimeric antigen receptor (CAR). The CAR used in this study can recognize CD22, a protein expressed on the surface of leukemia and lymphoma cells. The phase 1 part of this study will determine the safety and appropriate dose level of these CAR T cells, and the phase 2 part of the study will determine how effective this CAR T cell therapy is. Both patients who have never had prior CAR T cell therapy and those who have had prior CAR T cell therapy may be eligible to participate in this study.
Recruiting1 award Phase 1 & 215 criteria
More about Jodi L. Skiles
Clinical Trial Related6 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Jodi L. Skiles has experience with
- Alemtuzumab
- Fludarabine
- Melphalan
- Tisagenlecleucel
- Haploidentical Hematopoietic Cell Transplantation (haploHCT)
- Matched Unrelated Donor Hematopoietic Cell Transplantation (MUD-HCT)
Breakdown of trials Jodi L. Skiles has run
Adult T-Cell Leukemia/Lymphoma
Acute Lymphoblastic Leukemia
Leukemia
Lymphoma
Lymphocytic Leukemia
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