Dr. Austin T Robinson, PhD
Claim this profileAuburn University
Studies High Blood Pressure
Studies Hypertension
5 reported clinical trials
4 drugs studied
Affiliated Hospitals
Clinical Trials Austin T Robinson, PhD is currently running
Ketone Supplements
for High Blood Pressure
Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs the ability of systemic blood vessels and the kidneys to control blood pressure, which contributes to excess salt consumption being associated with increased risk for chronic kidney disease and cardiovascular disease, the leading cause of death in America. There is a critical need for strategies to counteract the effects of high dietary salt as consumption is likely not going to decrease. One promising option is ketones, metabolites that are produced in the liver during prolonged exercise and very low-calorie diets. While exercise and low-calorie diets are beneficial, not many people engage in these activities. However, limited evidence indicates that ketone supplements improve cardiovascular health in humans. Additionally published rodent data indicates that ketone supplements prevent high salt-induced increases in blood pressure, blood vessel dysfunction, and kidney injury. Our human pilot data also indicates that high dietary salt reduces intrinsic ketone production, but it is unclear whether ketone supplementation confers humans protection against high salt similar to rodents. Therefore, the investigators seek to conduct a short-term high dietary salt study to determine whether ketone supplementation prevents high dietary salt from eliciting increased blood pressure, blood vessel dysfunction, and kidney injury/impaired blood flow. The investigators will also measure inflammatory markers in blood samples and isolate immune cells that control inflammation. Lastly, the investigators will also measure blood ketone concentration and other circulating metabolites that may be altered by high salt, which could allow us to determine novel therapeutic targets to combat high salt.
Recruiting1 award N/A6 criteria
Salt Intake
for High Blood Pressure Differences by Race
This IRB will cover a current clinical trial (NCT04244604) that was started at Auburn University (AU IRB#19-390), the Principal Investigator's prior institution, and is supported by his NIH Career Development Award (NHLBI K01HL147998). About nine out of ten Americans overconsume dietary salt. Compared to other racial groups, Black individuals are more prone to salt-sensitive hypertension and negative cardiovascular conditions associated with high salt intake. However, there is a critical need to determine the reasons behind and mechanisms that contribute to these racial disparities. Both acute (single meal) and chronic high-dietary sodium cause small but important increases in blood sodium concentration that are associated with altered blood pressure regulation and blood vessel dysfunction. However, racial differences in these measures have not been examined. This is important because Black individuals generally exhibit lower circulating concentrations of hormones (e.g., renin, aldosterone, angiotensin 2) that buffer changes in body sodium to regulate blood pressure, and this could make them more vulnerable to the negative effects of a high-sodium meal. Therefore, the purpose of this study is to determine whether there are racial differences in blood pressure regulation and blood flow after a high-sodium meal. The investigators will assess blood pressure regulation, blood vessel stiffness, and the blood vessel's ability to dilate before and after a high-salt meal and a low-salt control meal (both meals are low-salt tomato soup with varied added salt). The investigators will also collect blood and urine to measure sodium and determine biochemical changes that may be contributing to racial differences in cardiovascular function.
Recruiting1 award N/A6 criteria
More about Austin T Robinson, PhD
Clinical Trial Related2 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Austin T Robinson, PhD has experience with
- MitoQ
- Β-OHB
- Acute Salt (sodium Chloride)
- Sleep Extension
Breakdown of trials Austin T Robinson, PhD has run
High Blood Pressure
Hypertension
Vascular Disorders
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Austin T Robinson, PhD specialize in?
Austin T Robinson, PhD focuses on High Blood Pressure and Hypertension. In particular, much of their work with High Blood Pressure has involved treating patients, or patients who are undergoing treatment.
Is Austin T Robinson, PhD currently recruiting for clinical trials?
Yes, Austin T Robinson, PhD is currently recruiting for 3 clinical trials in Auburn Alabama. If you're interested in participating, you should apply.
Are there any treatments that Austin T Robinson, PhD has studied deeply?
Yes, Austin T Robinson, PhD has studied treatments such as MitoQ, β-OHB, Acute Salt (sodium chloride).
What is the best way to schedule an appointment with Austin T Robinson, PhD?
Apply for one of the trials that Austin T Robinson, PhD is conducting.
What is the office address of Austin T Robinson, PhD?
The office of Austin T Robinson, PhD is located at: Auburn University, Auburn, Alabama 36849 United States. This is the address for their practice at the Auburn University.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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