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Trial Phase
Trial Status
Paid Participation
45 Migraine Trials Near You
Power is an online platform that helps thousands of Migraine patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.
Learn More About PowerMind-Body Balance for Pediatric Migraine
Trial Details
Key Eligibility Criteria
260 Participants Needed
Eptinezumab for Migraine
Trial Details
Key Eligibility Criteria
150 Participants Needed
Erenumab for Migraine
Trial Details
Key Eligibility Criteria
284 Participants Needed
Mindfulness Therapy for Migraines
Trial Details
Key Eligibility Criteria
144 Participants Needed
Rimegepant for Migraine
Trial Details
Key Eligibility Criteria
200 Participants Needed
Rimegepant for Migraine Prevention
Trial Details
Key Eligibility Criteria
658 Participants Needed
Rimegepant for Migraine
Trial Details
Key Eligibility Criteria
633 Participants Needed
IPN10200 for Migraine Prevention
Trial Details
Key Eligibility Criteria
641 Participants Needed
Behavioral Interventions for Chronic Migraine
Trial Details
Key Eligibility Criteria
300 Participants Needed
Brain Stimulation for Migraine
Trial Details
Key Eligibility Criteria
80 Participants Needed
MMA Embolization for Migraine
Trial Details
Key Eligibility Criteria
50 Participants Needed
Rimegepant for Menstrual Migraine
Trial Details
Key Eligibility Criteria
723 Participants Needed
Atogepant for Migraine
Trial Details
Key Eligibility Criteria
420 Participants Needed
MTX101 for Migraine
Trial Details
Key Eligibility Criteria
72 Participants Needed
MEDI0618 for Migraine
Trial Details
Key Eligibility Criteria
12 Participants Needed
Why Other Patients Applied
"I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."
"My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."
"I've been struggling with ADHD and anxiety since I was 9 years old. I'm currently 30. I really don't like how numb the medications make me feel. And especially now, that I've lost my grandma and my aunt 8 days apart, my anxiety has been even worse. So I'm trying to find something new."
"As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."
"I was diagnosed with stage 4 pancreatic cancer three months ago, metastatic to my liver, and I have been receiving and responding well to chemotherapy. My blood work revealed that my tumor markers have gone from 2600 in the beginning to 173 as of now, even with the delay in treatment, they are not going up. CT Scans reveal they have been shrinking as well. However, chemo is seriously deteriorating my body. I have 4 more treatments to go in this 12 treatment cycle. I am just interested in learning about my other options, if any are available to me."
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We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.
Frequently Asked Questions
How much do Migraine clinical trials pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.
How do Migraine clinical trials work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Migraine trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Migraine is 12 months.
How do I participate in a study as a "healthy volunteer"?
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.
What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.
Do I need to be insured to participate in a Migraine medical study?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
What are the newest Migraine clinical trials?
Most recently, we added MMA Embolization for Migraine, Rimegepant for Menstrual Migraine and Elismetrep for Migraine to the Power online platform.
What are the current treatments for migraines?
Migraine care has two parts: 1) fast-acting medicines for an attack, which range from simple pain relievers to triptans, newer CGRP blockers (ubrogepant, rimegepant), the ditan lasmiditan, ergotamine/DHE, and even handheld nerve-stimulation devices; and 2) preventive strategies taken regularly—beta-blockers, anti-seizure or antidepressant drugs, CGRP monoclonal-antibody injections, atogepant tablets, Botox, plus consistent sleep, exercise and trigger management—to cut down how often headaches occur. Doctors match these tools to your migraine frequency, other health conditions and side-effect risks, and will step up to preventive therapy if you still have about four or more disabling headache days per month.
What is the root cause of migraine?
Migraine starts with an inherited “hyper-excitable” brain network—particularly in the brain-stem and trigeminal pain pathways—that can be set off by waves of nerve activity (called cortical spreading depression) and the release of pain chemicals like CGRP. Hormone shifts, lack of sleep, certain foods, or stress don’t create the disease; they simply lower the threshold and provoke attacks in someone who already has this biological vulnerability. Knowing this helps you focus on both preventive medicines that calm those brain pathways and lifestyle steps that avoid personal triggers.
What is a chronic migraine that won't go away?
Chronic migraine means you suffer headaches on 15 or more days each month for at least three months, with at least eight of those days having typical migraine features; it is a long-term pattern, not a single marathon attack (that latter problem is called status migrainosus). The condition is usually tackled by limiting trigger factors and medication-overuse while starting a preventive treatment—such as daily oral drugs, periodic Botox injections, or the newer once-monthly CGRP antibody shots—under the guidance of a neurologist or headache specialist. Seek urgent care if any single attack lasts beyond 72 hours or suddenly feels different, as that could signal status migrainosus or another emergency.
Does drinking electrolytes help with migraines?
Electrolyte drinks are useful mainly when a migraine is brought on by dehydration—replacing both water and minerals can shorten or stop those attacks. Research shows only magnesium (about 400–600 mg a day) has real preventive benefit; extra sodium or potassium hasn’t been proven helpful and can be risky if you have heart, kidney or blood-pressure issues. Aim for steady daily hydration, use an electrolyte solution after heavy sweating or illness, and check with your doctor before taking regular magnesium or high-salt products.
What are the 5 C's of migraines?
The “5 C’s” are five foods and drinks that some people notice can spark a migraine: cheese, chocolate, coffee, cola (or other caffeinated soft drinks), and citrus fruits. They are only possible triggers—each one bothers certain individuals because of ingredients like tyramine or caffeine—so the practical way to find out if they affect you is to log what you eat and when headaches start, then review that pattern with your healthcare provider before cutting anything out.
Do migraines get worse with age?
For most people migraines are worst in their 20s-40s and slowly ease after about age 50, particularly once the hormonal ups-and-downs of perimenopause settle. That said, attacks can flare at any age if triggers pile up—hormone shifts, stress, poor sleep, or frequent use of pain relievers—so a new or noticeably different headache pattern after 50 deserves a medical check-up to rule out other causes. Keeping a trigger diary, limiting acute medicines, and asking your clinician about modern preventives (from CGRP blockers to lifestyle coaching) can stop migraines from feeling “worse with age.”
Why can't we cure migraines?
Migraine isn’t one simple defect but a tangle of many factors—dozens of genes, changing hormones, brain-wave events like “cortical spreading depression,” and pain chemicals such as CGRP—so blocking a single switch can’t cure every patient without also risking side-effects. Instead, doctors manage it by combining quick-relief drugs (triptans, newer CGRP blockers) with preventives (CGRP antibodies, beta-blockers, Botox, nerve-stimulation devices) while researchers keep mapping the circuitry to design even more targeted fixes. In short: we can’t yet erase migraine for everyone, but understanding is growing fast and today’s tailored treatments already let many people live nearly attack-free.
What are G pants for migraines?
“G-pants” is a nickname for “gepants,” a new group of oral (and one nasal-spray) migraine drugs—ubrogepant, rimegepant, atogepant and zavegepant—that block the CGRP receptor, a chemical switch that helps trigger migraine pain. Taken either at the start of an attack (ubrogepant, rimegepant, zavegepant) or once daily/every other day to cut the number of attacks (atogepant, rimegepant), they offer relief without the blood-vessel-tightening risk of older triptans; the most typical side-effects are mild nausea, fatigue or taste changes. Ask your doctor whether gepants fit your situation, especially if you have heart-disease risks or haven’t done well on triptans.
How do you break a chronic migraine?
Think of it in two steps. 1) If a migraine has dragged on for 3-plus days, a headache specialist can “break” it with short-term measures such as a triptan or NSAID taken early, a brief oral steroid taper, or in clinic/ER infusions like dihydroergotamine, IV metoclopramide, or a newer “gepant” pill; these reset the attack without causing medication-overuse headache. 2) To keep it from becoming chronic again, you need daily prevention tailored to you—common options are onabotulinumtoxinA shots or once-monthly CGRP-antibody injections, strict trigger and sleep hygiene, and limiting pain pills to <10 days a month—reviewed every few months with a headache specialist.
What toxin is used for migraines?
Doctors use onabotulinumtoxinA, best known by the brand name Botox, to prevent chronic migraine—defined as at least 15 headache days a month—when standard preventive medicines haven’t helped. Every 12 weeks a neurologist injects tiny amounts into about 31 spots across the scalp, forehead, and neck; this can cut monthly headache days by roughly 7-9 days, with the most common side-effects being temporary neck pain or mild eyelid droop. Ask your headache specialist whether you meet the criteria and whether any other medical conditions or medications would make this treatment unsuitable for you.