No Placebo

Highly Paid

Stay on Current Meds

Pivotal Trials (Near Approval)

Breakthrough Medication

Cincinnati, Ohio

The purpose of this study is to assess the long-term safety and effectiveness of odevixibat in participants with Alagille syndrome (ALGS). The participants of this study will have ALGS a rare genetic disorder that can affect multiple organ systems of the body including the liver, heart, skeleton, eyes and kidneys. Common symptoms, which often develop during the first three months of life, include blockage of the flow of bile from the liver (cholestasis), yellowing of the skin and mucous membranes (jaundice), poor weight gain and growth and severe itching (pruritis). The drug used for the study is odevixibat and was authorized for the treatment of cholestatic pruritus in infants with ALGS over 12 months of age by the United States Food and Drug Administration on 13 June 2023.

No Placebo Group

Pivotal Trial (Near Approval)

Trial Details

Trial Status:Recruiting

Trial Phase:Phase 3

Key Eligibility Criteria

Disqualifiers:Decompensated Liver Disease, Cancer, Others

Must Not Be Taking:Bile Acid Resins

70 Participants Needed

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Unbiased Results

We believe in providing patients with all the options.

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We only share your information with the clinical trials you're trying to access.

Verified Trials Only

All of our trials are run by licensed doctors, researchers, and healthcare companies.

1045 Sansome St, Suite 321, San Francisco, CA

hello@withpower.com (415) 900-4227

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1 Alagille Syndrome Trial Near You

Power is an online platform that helps thousands of Alagille Syndrome patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.

Why Other Patients Applied

"I changed my diet in 2020 and I’ve lost 95 pounds from my highest weight (283). I am 5’3”, female, and now 188. I still have a 33 BMI. I've been doing research on alternative approaches to continue my progress, which brought me here to consider clinical trials."

Obesity PatientAge: 58

"I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."

Depression PatientAge: 51

"My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."

Arthritis PatientAge: 78

"As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."

Healthy Volunteer PatientAge: 38

"I have dealt with voice and vocal fold issues related to paralysis for over 12 years. This problem has negatively impacted virtually every facet of my life. I am an otherwise healthy 48 year old married father of 3 living. My youngest daughter is 12 and has never heard my real voice. I am now having breathing issues related to the paralysis as well as trouble swallowing some liquids. In my research I have seen some recent trials focused on helping people like me."

Paralysis PatientAge: 50

Frequently Asked Questions

How much do Alagille Syndrome clinical trials pay?

Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.

How do Alagille Syndrome clinical trials work?

After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Alagille Syndrome trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Alagille Syndrome is 12 months.

How do I participate in a study as a "healthy volunteer"?

Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.

What does the "phase" of a clinical trial mean?

The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.

Do I need to be insured to participate in a Alagille Syndrome medical study?

Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.

What are the newest Alagille Syndrome clinical trials?

Most recently, we added Odevixibat for Alagille Syndrome to the Power online platform.

How much do Alagille Syndrome clinical trials pay?

How do Alagille Syndrome clinical trials work?

How do I participate in a study as a "healthy volunteer"?

What does the "phase" of a clinical trial mean?

Do I need to be insured to participate in a Alagille Syndrome medical study?

What are the newest Alagille Syndrome clinical trials?

Most recently, we added Odevixibat for Alagille Syndrome to the Power online platform.

Learn More About Power

Learn More About Power

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1 Alagille Syndrome Trial Near You

Power is an online platform that helps thousands of Alagille Syndrome patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.

1 Alagille Syndrome Trial Near You

Power is an online platform that helps thousands of Alagille Syndrome patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.

Why Other Patients Applied

Frequently Asked Questions

How much do Alagille Syndrome clinical trials pay?

How do Alagille Syndrome clinical trials work?

How do I participate in a study as a "healthy volunteer"?

What does the "phase" of a clinical trial mean?

Do I need to be insured to participate in a Alagille Syndrome medical study?

What are the newest Alagille Syndrome clinical trials?

How much do Alagille Syndrome clinical trials pay?

How do Alagille Syndrome clinical trials work?

How do I participate in a study as a "healthy volunteer"?

What does the "phase" of a clinical trial mean?

Do I need to be insured to participate in a Alagille Syndrome medical study?

What are the newest Alagille Syndrome clinical trials?

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