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Virginia Cancer Specialists

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Fairfax, Virginia 22031

Global Leader in Lung Cancer

Global Leader in Solid Tumors

Conducts research for Non-Small Cell Lung Cancer

Conducts research for Cancer

Conducts research for Pancreatic Cancer

440 reported clinical trials

19 medical researchers

Photo of Virginia Cancer Specialists in FairfaxPhoto of Virginia Cancer Specialists in FairfaxPhoto of Virginia Cancer Specialists in Fairfax

Summary

Virginia Cancer Specialists is a medical facility located in Fairfax, Virginia. This center is recognized for care of Lung Cancer, Solid Tumors, Non-Small Cell Lung Cancer, Cancer, Pancreatic Cancer and other specialties. Virginia Cancer Specialists is involved with conducting 440 clinical trials across 331 conditions. There are 19 research doctors associated with this hospital, such as Alexander Spira, MD, Alex Spira, MD, PhD, Mitul Gandhi, and M. Adham Salkeni, MD, FRCPC.

Area of expertise

1

Lung Cancer

Global Leader

Virginia Cancer Specialists has run 245 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage III
EGFR positive
2

Solid Tumors

Global Leader

Virginia Cancer Specialists has run 199 trials for Solid Tumors. Some of their research focus areas include:

Stage IV
Stage III
KRAS positive

Top PIs

Clinical Trials running at Virginia Cancer Specialists

Lung Cancer

Breast Cancer

Solid Tumors

Cancer

Ovarian Cancer

Non-Small Cell Lung Cancer

Pancreatic Cancer

Endometrial Cancer

Colorectal Cancer

Melanoma

Image of trial facility.

Zongertinib

for Lung Cancer

This study is open to adults 18 years and older who have early-stage non-small cell lung cancer (NSCLC). Their cancer must have a specific change in a gene called HER2. Genes provide the instructions for making proteins, and this change leads to a faulty HER2 protein. People can join if their lung cancer was removed by surgery, and they have already received certain other anti-cancer treatments. The purpose of this study is to find out if a study medicine called zongertinib helps people with this type of cancer live longer without their cancer coming back after surgery, when compared to standard treatment. Zongertinib is being developed to target the faulty HER2 protein, which can cause cancer cells to grow. In this study, participants are assigned by chance to one of two treatment groups, with an equal chance of being in either group. One group takes the study medicine, zongertinib, by mouth once a day for up to 3 years. The other group receives a standard treatment, chosen by their doctor. This standard treatment may be an immunotherapy medicine given by infusion into a vein every 3 or 4 weeks for up to 1 year, or regular check-ups without active study medicine (observation). Participants can be in this study for up to about 11 years. During this time, they visit the study site regularly for check-ups and study-related tests. The frequency of these visits varies depending on their treatment and how long they have been in the study. In addition to visits at the study site, participants in some treatment groups will also have phone calls with the study team every 3 weeks to check on their health between their scheduled visits. Doctors check for any signs of cancer coming back using imaging scans (like CT or MRI scans); these scans are generally done every 3 months for the first 2 years, then every 6 months for the next 3 years, and then yearly. Participants also fill in questionnaires about their overall wellbeing, health and symptoms. Throughout the study, doctors also check participants' health and note any unwanted effects.

Recruiting

2 awards

Phase 3

6 criteria

Image of trial facility.

Zongertinib

for Lung Cancer

This study is open to adults 18 years and older with advanced or metastatic non-small cell lung cancer. People can join the study if they have tumours with HER2 mutations and have not yet received any systemic therapy including chemotherapy for advanced or metastatic lung cancer. The purpose of this study is to find out whether a medicine called zongertinib (BI 1810631) can slow down the worsening of advanced non-small cell lung cancer better than the standard treatment available. Zongertinib may slow cancer cell growth by inhibiting HER2. This would prolong cancer re-occurrence and increase survival. Current standard treatment is pembrolizumab plus platinum-pemetrexed chemotherapy. Participants are put into 2 groups by chance. One group receives zongertinib at regular times throughout the study and the other group receives infusions of pembrolizumab, pemetrexed and cisplatin or carboplatin (pembrolizumab plus platinum-pemetrexed chemotherapy) into a vein. Participants may be in the study up to a maximum of 70 months. During this time, they visit the study site about every 3 weeks for study procedures. The doctors regularly check the size of the tumour with a CT or MRI scan, at the beginning of the study and every 6 weeks. After 18 months they check the tumour size every 12 weeks. Doctors regularly check whether the cancer has spread to other parts of the body. The doctors also regularly check participants' health and take note of any unwanted effects. The time it takes for the cancer to worsen is compared between the 2 groups to see whether the treatment works. The participants also fill in questionnaires about their symptoms and quality of life.

Recruiting

2 awards

Phase 3

9 criteria

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Multiple Therapies

for Stage III Non-Small Cell Lung Cancer

This trial is testing different treatments to see how well they work and how safe they are. It focuses on patients with advanced lung cancer that cannot be removed by surgery and have specific biological markers. The goal is to find out if these treatments can stop the cancer from growing or spreading and improve patients' health.

Recruiting

2 awards

Phase 3

17 criteria

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