Study Summary
This trial will test how well different therapies work in treating people with Stage III NSCLC that has spread and cannot be removed by surgery.
- Non-Small Cell Lung Cancer
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 14 Secondary · Reporting Duration: From randomization to the first deterioration of >/= 10 points that is either maintained for two consecutive assessments or followed by death from any cause within 3 weeks (up to 3 years)
Trial Safety
Safety Progress
Side Effects for
Trial Design
6 Treatment Groups
Cohort A1: ALK-positive (durvalumab arm)
1 of 6
Cohort A2: ROS 1-positive (durvalumab arm)
1 of 6
Cohort A3: RET fusion-positive (durvalumab arm)
1 of 6
Cohort A3: RET fusion-positive (pralsetinib arm)
1 of 6
Cohort A1: ALK-Positive (alectinib arm)
1 of 6
Cohort A2: ROS 1-positive (entrectinib arm)
1 of 6
Active Control
Experimental Treatment
320 Total Participants · 6 Treatment Groups
Primary Treatment: Alectinib · No Placebo Group · Phase 3
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 18 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
What are the dangers that Alectinib poses to patients?
"Alectinib's safety is corroborated by its Phase 3 status, and it received a score of 3." - Anonymous Online Contributor
What medical conditions does Alectinib usually treat?
"Alectinib is most commonly used to treat solid tumors. It can also be prescribed to patients with malignant neoplasms, for those who have had an unsuccessful surgical resection, or for medullary carcinoma of the thyroid." - Anonymous Online Contributor
Are patients being actively recruited for this experiment as of now?
"That is correct, the clinical trial mentioned is recruiting patients as of right now. The original posting was on November 1st, 2022 and there has since been an update on recruitment numbers and sites. Currently, 11 centres are looking for 320 individuals to participate." - Anonymous Online Contributor
What other scientific papers have been published that mention Alectinib?
"As of now, Alectinib is being trialed in 371 separate studies. Out of those active trials, 58 have reached Phase 3 status. The primary locations for these trial are Cordoba and Texas; though, there are 15733 sites running clinical trials for this medication globally." - Anonymous Online Contributor
Is this trial also being conducted in other parts of Canada?
"There are 11 available for this trial such as Thompson Cancer Survival Center in Knoxville, Henry Ford Health System in Detroit, and UCLA Department of Medicine in Los Angeles." - Anonymous Online Contributor
How many individuals are part of this experiment?
"320 participants that meet the study's requirements are necessary to conduct this research. Hoffmann-La Roche, the sponsor of the trial, will be running it from various locations including Thompson Cancer Survival Center in Knoxville, Tennessee and Henry Ford Health System in Detroit, Michigan." - Anonymous Online Contributor