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VA San Diego Healthcare System, San Diego, CA
Claim this profileSan Diego, California 92103
Global Leader in Post-Traumatic Stress Disorder
Global Leader in Depression
Conducts research for Schizophrenia
Conducts research for Traumatic Brain Injury
Conducts research for Bipolar Disorder
225 reported clinical trials
32 medical researchers
Summary
VA San Diego Healthcare System, San Diego, CA is a medical facility located in San Diego, California. This center is recognized for care of Post-Traumatic Stress Disorder, Depression, Schizophrenia, Traumatic Brain Injury, Bipolar Disorder and other specialties. VA San Diego Healthcare System, San Diego, CA is involved with conducting 225 clinical trials across 331 conditions. There are 32 research doctors associated with this hospital, such as Leslie A. Morland, PsyD, Peter Colvonen, MD, Catherine R Ayers, PhD, and Ariel J. Lang, PhD.Top PIs
Leslie A. Morland, PsyDVA San Diego Healthcare System, San Diego, CA1 year of reported clinical research
Studies Post-Traumatic Stress Disorder
Studies Relationship Issues
5 reported clinical trials
7 drugs studied
Peter Colvonen, MDVA San Diego Healthcare System, San Diego, CA2 years of reported clinical research
Studies Post-Traumatic Stress Disorder
Studies Apnea
4 reported clinical trials
6 drugs studied
Catherine R Ayers, PhDVA San Diego Healthcare System, San Diego, CA5 years of reported clinical research
Studies Obsessive Hoarding
Studies Hoarding Disorder
3 reported clinical trials
6 drugs studied
Ariel J. Lang, PhDVA San Diego Healthcare System, San Diego, CA2 years of reported clinical research
Studies Post-Traumatic Stress Disorder
Studies Life Stress
3 reported clinical trials
6 drugs studied
Clinical Trials running at VA San Diego Healthcare System, San Diego, CA
Post-Traumatic Stress Disorder
Insomnia
Bipolar Disorder
Suicide Attempt
Suicide
Psychosis
SHOX Deficiency Disorder
Clostridium Difficile Infection
Parkinson's Disease
Atherosclerosis
Prolonged Exposure Therapy + Medication
for PTSD
Posttraumatic Stress Disorder (PTSD) remains a salient and debilitating problem, in the general population and for military veterans in particular. Several psychological and pharmacological treatments for PTSD have evidence to support their efficacy. However, the lack of comparative effectiveness data for PTSD treatments remains a major gap in the literature, which limits conclusions that can be drawn about which of these treatments work best. The current study will compare the effectiveness of PTSD treatments with the strongest evidentiary support - Prolonged Exposure (PE) therapy and pharmacotherapy with paroxetine or venlafaxine - as well as the combination of these two treatments. A randomized trial will be conducted with a large, diverse sample of veterans with PTSD (N = 300) recruited from 6 VA Medical Centers throughout the US. Participants will complete baseline assessments, followed by an active treatment phase (involving up to 14 sessions of PE and/or medication management) with mid (7 week) and posttreatment (14 week) assessments, and follow-up assessments at 27 and 40 weeks. Study outcomes will include PTSD severity, depression, quality of life and functioning, assessed via clinical ratings and self-report measures. Further, a range of demographic and clinically relevant variables (e.g., trauma type/number, resilience) will be collected at baseline and examined as potential predictors or moderators of treatment response, addressing another gap in the PTSD treatment literature. These data will be used to develop algorithms from predicting the optimal treatment for individual patients (i.e., "personalized advantage indices"; PAIs). Effectiveness of the treatments will be compared using multilevel modeling. PAIs will be developed by conducting bootstrapped analyses to select variables that predict or moderate outcomes (clinician rated PTSD severity at Week 14), followed by jacknife analyses to determine the magnitude of the predicted difference (representing an individual's "predicted advantage" of one treatment over the others).
Recruiting3 awards Phase 44 criteria
Lorazepam
for PTSD
A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications. Progress in developing more effective medications is hampered by the substantial variability within Veterans with PTSD, meaning the most effective medication likely varies from individual to individual. New scientific tools to help identify distinct subgroups of Veterans with PTSD who are likely to respond to specific medications could help improve treatment in this population. Research has indicated that a specific subgroup of Veterans with PTSD with a high level of anxious arousal may benefit from medications which boost signaling of the neurotransmitter gamma-aminobutyric acid (GABA). This project aims to validate a clinical test to identify these individuals using new computational and neuroimaging methods combined with the medication lorazepam, a positive GABA modulator. The ultimate goal is to use these methods in future clinical trials of new medications to target the best treatments to individual Veterans with PTSD.
Recruiting2 awards Phase 41 criteria
CBD + Prolonged Exposure
for PTSD
The trial will include a randomized control trial to evaluate the efficacy of using Cannabidiol (CBD), a non-intoxicating cannabinoid, as an adjunctive to Prolonged Exposure therapy (PE). The trial will compare PE + CBD to PE + placebo in a sample of 136 military Veterans with PTSD at the VA San Diego Medical Center. The study represents the logical and innovative next step for augmenting existing treatments and developing novel pharmacotherapy for PTSD. Findings from the proposed RCT will inform clinical practice and policy by investigating whether administration of CBD in the context of PE therapy will improve treatment outcomes for military Veterans with PTSD.
Recruiting2 awards Phase 2
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Frequently asked questions
What kind of research happens at VA San Diego Healthcare System, San Diego, CA?
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.