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Rady Children's Hospital - San Diego
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San Diego, California 92123
Global Leader in Acute Lymphoblastic Leukemia
Global Leader in Brain Tumor
Conducts research for Cancer
Conducts research for Neuroblastoma
Conducts research for Leukemia
494 reported clinical trials
42 medical researchers
Summary
Rady Children's Hospital - San Diego is a medical facility located in San Diego, California. This center is recognized for care of Acute Lymphoblastic Leukemia, Brain Tumor, Cancer, Neuroblastoma, Leukemia and other specialties. Rady Children's Hospital - San Diego is involved with conducting 494 clinical trials across 791 conditions. There are 42 research doctors associated with this hospital, such as William D. Roberts, Deborah Schiff, Eric Anderson, and John Crawford, MD, MS.
Area of expertise
Acute Lymphoblastic Leukemia
Rady Children's Hospital - San Diego has run 52 trials for Acute Lymphoblastic Leukemia. Some of their research focus areas include:
Brain Tumor
Rady Children's Hospital - San Diego has run 52 trials for Brain Tumor. Some of their research focus areas include:
Top PIs
William D. Roberts
Rady Children's Hospital - San Diego
8 years of reported clinical research
Deborah Schiff
Rady Children's Hospital and Health Center
10 years of reported clinical research
Eric Anderson
North Colorado Medical Center
7 years of reported clinical research
John Crawford, MD, MS
Rady Children's Hospital
12 years of reported clinical research
Clinical Trials running at Rady Children's Hospital - San Diego
Neuroblastoma
Cancer
Leukemia
Testicular cancer
Brain Tumor
Solid Tumors
Prader-Willi Syndrome
Brain Cancer
Acute Lymphoblastic Leukemia
Acute Leukemia
Dinutuximab + Chemotherapy
for High-Risk Neuroblastoma
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab binds to the neuroblastoma cells, it helps signal the immune system to kill the tumor cells. This helps the cells of the immune system kill the cancer cells, this is a type of immunotherapy. When chemotherapy and immunotherapy are given together, during the same treatment cycle, it is called chemoimmunotherapy. This clinical trial randomly assigns patients to receive either standard chemotherapy and surgery or chemoimmunotherapy (chemotherapy plus dinutuximab) and surgery during Induction therapy. Chemotherapy drugs administered during Induction include, cyclophosphamide, topotecan, cisplatin, etoposide, vincristine, and doxorubicin. These drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing or by stopping them from spreading. Upon completion of 5 cycles of Induction therapy, a disease evaluation is completed to determine how well the treatment worked. If the tumor responds to therapy, patients receive a tandem transplantation with stem cell rescue. If the tumor has little improvement or worsens, patients receive chemoimmunotherapy on Extended Induction. During Extended Induction, dinutuximab is given with irinotecan, temozolomide. Patients with a good response to therapy move on to Consolidation therapy, when very high doses of chemotherapy are given at two separate points to kill any remaining cancer cells. Following, transplant, radiation therapy is given to the site where the cancer originated (primary site) and to any other areas that are still active at the end of Induction. The final stage of therapy is Post-Consolidation. During Post-Consolidation, dinutuximab is given with isotretinoin, with the goal of maintaining the response achieved with the previous therapy. Adding dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy may be better at treating children with newly diagnosed high-risk neuroblastoma.
Recruiting
2 awards
Phase 3
7 criteria
Lorlatinib + Standard Therapy
for Neuroblastoma
This phase III trial studies iobenguane I-131 or lorlatinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Lorlatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving iobenguane I-131 or lorlatinib and standard therapy may work better compared to lorlatinib and standard therapy alone in treating younger patients with neuroblastoma or ganglioneuroblastoma.
Recruiting
2 awards
Phase 3
22 criteria
DFMO Maintenance Therapy
for Neuroblastoma
This trial tests a medication called DFMO in patients with high-risk neuroblastoma who are in remission. The goal is to prevent the cancer from returning by stopping an enzyme that cancer cells need to grow. DFMO was initially developed as a cancer therapeutic agent but gained renewed interest as a preventive agent after showing effectiveness in inhibiting cancer development in rodent models.
Recruiting
1 award
Phase 2
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Frequently asked questions
What kind of research happens at Rady Children's Hospital - San Diego?
Rady Children's Hospital - San Diego is a medical facility located in San Diego, California. This center is recognized for care of Acute Lymphoblastic Leukemia, Brain Tumor, Cancer, Neuroblastoma, Leukemia and other specialties. Rady Children's Hospital - San Diego is involved with conducting 494 clinical trials across 791 conditions. There are 42 research doctors associated with this hospital, such as William D. Roberts, Deborah Schiff, Eric Anderson, and John Crawford, MD, MS.
Where is Rady Children's Hospital - San Diego located?
**Directions to Rady Children's Hospital - San Diego:** - From the 805 North, exit at Mesa College Drive and turn left. - At the next light, turn left onto Health Center Drive, then continue for one block. - The hospital is located at 3020 Children's Way, San Diego, CA 92123.
Who should I call to ask about financial aid or insurance network?
For financial assistance and insurance inquiries at Rady Children's Hospital - San Diego: - **Phone:** 858-966-4005 (Monday-Friday, 7 a.m.-10:30 p.m.; Saturday, 7 a.m.-8:30 p.m.; Sunday, 7 a.m.-3:30 p.m.) - **Mail:** 3020 Children’s Way, MC 5055, San Diego, California, 92123 Financial counseling services are available to assist with government-sponsored health benefit programs, low-cost health insurance, and payment plans. Eligibility is based on family income and needs, including certain insured individuals with high medical costs.
What insurance does Rady Children's Hospital - San Diego accept?
Rady Children's Hospital - San Diego accepts a wide range of insurance plans, including but not limited to Aetna, Anthem Blue Cross, Blue Shield, Cigna, Health Net, Sharp Health Plan, Scripps Health Plan, and United Healthcare in various configurations (HMO/POS/Medi-Cal). It is also in-network for several Medi-Cal Health Plans, including Care 1st Health Plan, Community Health Group, Health Net Community Solutions, Kaiser Permanente, Molina Healthcare, and Standard Benefits Medi-Cal.
What awards or recognition has Rady Children's Hospital - San Diego received?
Rady Children's Hospital - San Diego is renowned for its exceptional patient experience, earning recognition from the Professional Research Consultants in 2019. It has achieved rankings in all 10 specialties surveyed by U.S. News & World Report. Notably, its Neonatology program is ranked No. 4 nationally, and its Orthopedics program is ranked No. 7.
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.