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University of Pennsylvania
Claim this profilePhiladelphia, Pennsylvania 19104
Global Leader in Human Immunodeficiency Virus Infection
Global Leader in Heart Failure
Conducts research for Cancer
Conducts research for HIV Infection
Conducts research for High Blood Pressure
1932 reported clinical trials
267 medical researchers
Summary
University of Pennsylvania is a medical facility located in Philadelphia, Pennsylvania. This center is recognized for care of Human Immunodeficiency Virus Infection, Heart Failure, Cancer, HIV Infection, High Blood Pressure and other specialties. University of Pennsylvania is involved with conducting 1,932 clinical trials across 2,247 conditions. There are 267 research doctors associated with this hospital, such as Nimesh Desai, MD, Arati Desai, MD, Angela DeMichele, MD, and Wilson Szeto, MD.Area of expertise
1Human Immunodeficiency Virus Infection
Global Leader2Heart Failure
Global LeaderStage II
Stage IV
Stage III
Top PIs
Nimesh Desai, MDUniversity of Pennsylvania4 years of reported clinical research
Studies Aortic Aneurysm
Studies Aortic Dissection
13 reported clinical trials
17 drugs studied
Arati Desai, MDAbrams Cancer Center of the University of Pennsylvania6 years of reported clinical research
Studies Brain Tumor
Studies Glioblastoma
11 reported clinical trials
25 drugs studied
Angela DeMichele, MDAbramson Cancer Center of the University of Pennsylvania8 years of reported clinical research
Expert in Breast Cancer
Studies Breast cancer
11 reported clinical trials
20 drugs studied
Wilson Szeto, MDThe Hospital of the University of Pennsylvania6 years of reported clinical research
Studies Pararenal Aneurysms
Studies Aortic Aneurysm
10 reported clinical trials
13 drugs studied
Clinical Trials running at University of Pennsylvania
Heart Failure
Colorectal Cancer
Age-Related Macular Degeneration
Pancreatic Cancer
Chronic Lymphocytic Leukemia
Atrial Fibrillation
Cancer
Cystic Fibrosis
Fibrosing Colonopathy
Lung Cancer
Catheter Ablation + HF Therapies
for Heart Failure and Atrial Fibrillation
Heart failure (HF) with preserved left ventricular function (pEF) is difficult clinical syndrome to treat effectively with few evidence based therapies. Atrial fibrillation (AF) is now an important co-morbidity being observed in 43% of patients with HFpEF. Rhythm control has not been studied in this population. Catheter ablation and antiarrhythmic drugs are rhythm control therapies that have been used for treatment of AF without HF or HF with reduced systolic function but have not been widely applied in HFpEF. No controlled comparative evaluation has been performed in HFpEF. The introduction of wireless pulmonary artery hemodynamic monitoring has permitted optimization of HF therapy in patients with chronic HF with reduced and preserved EF. Reduction in HF hospitalizations has been observed in post hoc analyses of HFpEF patients but has not been systematically applied in AF patients with HFpEF. In this study, we propose to study both rhythm control and optimized HF therapeutic approaches in an AF with HFpEF study population in a pilot study using a sequential two phase randomized controlled clinical trial design.
Recruiting3 awards Phase 413 criteria
Sitagliptin
for Type 2 Diabetes with Genetic Mutation
This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a mixed meal, and higher levels of intact DPP4 substrates compared to during placebo and compared to matched controls.
Recruiting2 awards Phase 43 criteria
Ziltivekimab
for Heart Failure and Inflammation
The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (inactive substance that looks like the study medicine but does not contain any medicine). The treatment participants get is decided by chance. Participant's chance of getting ziltivekimab or placebo is the same. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine that doctors cannot prescribe. The study is expected to last for up to 1 year and 4 months.
Recruiting1 award Phase 3
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Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.