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University of California Davis Comprehensive Cancer Center

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Sacramento, California 95817

Global Leader in Lung Cancer

Global Leader in Cancer

Conducts research for Breast Cancer

Conducts research for Solid Tumors

Conducts research for Pancreatic Cancer

870 reported clinical trials

39 medical researchers

Photo of University of California Davis Comprehensive Cancer Center in SacramentoPhoto of University of California Davis Comprehensive Cancer Center in SacramentoPhoto of University of California Davis Comprehensive Cancer Center in Sacramento

Summary

University of California Davis Comprehensive Cancer Center is a medical facility located in Sacramento, California. This center is recognized for care of Lung Cancer, Cancer, Breast Cancer, Solid Tumors, Pancreatic Cancer and other specialties. University of California Davis Comprehensive Cancer Center is involved with conducting 870 clinical trials across 790 conditions. There are 39 research doctors associated with this hospital, such as Marcio H. Malogolowkin, Edward J. Kim, Jonathan W. Riess, and Mamta Parikh.

Area of expertise

1

Lung Cancer

Global Leader

University of California Davis Comprehensive Cancer Center has run 165 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage III
Stage II
2

Cancer

Global Leader

University of California Davis Comprehensive Cancer Center has run 124 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage III
Stage I

Top PIs

Clinical Trials running at University of California Davis Comprehensive Cancer Center

Breast Cancer

Lung Cancer

Skin Cancer

Ovarian Cancer

Multiple Myeloma

Prostate Cancer

Breast cancer

Kidney Cancer

Cancer

Testicular cancer

Image of trial facility.

Carvedilol

for Preventing Heart Problems in HER2 Positive Breast Cancer

This trial has two cohorts of patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. All patients must be receiving trastuzumab-based treatment. Both cohorts are being observed for cardiac toxicity. The largest cohort (currently open to accrual) is observational, and contains patients who are taking a beta blocker, ACE inhibitor, or ARB as well as their trastuzumab-based treatment. The goal is to understand how common cardiac problems are in this group of patients at high risk. The smaller cohort (currently closed to accrual) is randomized. Patients in this second cohort are randomized to either carvedilol or no treatment, with the goal of seeing whether carvedilol (used to treat heart failure and high blood pressure) may prevent the heart from side effects of chemotherapy.

Recruiting

2 awards

Phase 3

23 criteria

Image of trial facility.

Low Dose Tamoxifen

for Breast Cancer

This phase III trial compares the effect of low dose tamoxifen to usual hormonal therapy, including aromatase inhibitors, in treating post-menopausal women with hormone positive, HER2 negative early stage breast cancer. Tamoxifen is in a class of medications known as antiestrogens. It blocks the activity of estrogen (a female hormone) in the breast. This may stop the growth of some breast tumors that need estrogen to grow. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, prevent the formation of estradiol, a female hormone, by interfering with an aromatase enzyme. Aromatase inhibitors are used as a type of hormone therapy to treat postmenopausal women with hormone-dependent breast cancer. Giving low dose tamoxifen may be more effective compared to usual hormone therapy in treating post-menopausal women with hormone-positive, HER2 negative early stage breast cancer.

Recruiting

2 awards

Phase 3

8 criteria

Image of trial facility.

HER2-Targeted Therapy

for Breast Cancer

This phase III trial compares 6 months of human epidermal growth factor receptor 2 (HER2)-targeted therapy to 12 months of HER2-targeted therapy for the treatment of HER2-positive (+) breast cancer in patients that had a pathologic complete response (pCR) after preoperative (neoadjuvant) chemotherapy with trastuzumab. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to a receptor protein called HER2. HER2 is found on some cancer cells. When trastuzumab or pertuzumab attach to HER2, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving 6 months of HER2-targeted therapy may work better than giving 12 months for the treatment of HER2+ breast cancer in patients that had a pCR after neoadjuvant chemotherapy with trastuzumab.

Recruiting

2 awards

Phase 3

5 criteria

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