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EDMONTON

University of Alberta Hospital

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EDMONTON, Alberta T6G 2B7

Global Leader in Stroke

Global Leader in Cancer

Conducts research for Crohn's Disease

Conducts research for Acute Myelogenous Leukemia

Conducts research for Acute Myeloid Leukemia

425 reported clinical trials

91 medical researchers

Photo of University of Alberta Hospital in EDMONTONPhoto of University of Alberta Hospital in EDMONTONPhoto of University of Alberta Hospital in EDMONTON

Summary

University of Alberta Hospital is a medical facility located in EDMONTON, Alberta. This center is recognized for care of Stroke, Cancer, Crohn's Disease, Acute Myelogenous Leukemia, Acute Myeloid Leukemia and other specialties. University of Alberta Hospital is involved with conducting 425 clinical trials across 1,132 conditions. There are 91 research doctors associated with this hospital, such as Sarah J. McKillop, Brian H. Buck, MD, FRCPC, Tim Darsaut, MD, and Eric Wong, MD.

Area of expertise

1

Stroke

Global Leader

University of Alberta Hospital has run 52 trials for Stroke.

2

Cancer

Global Leader

University of Alberta Hospital has run 31 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage I
Stage II

Top PIs

Clinical Trials running at University of Alberta Hospital

Acute Lymphoblastic Leukemia

Testicular cancer

Crohn's Disease

Stroke

Atrial Fibrillation

Ovarian Carcinoma

Ovarian Tumors

Testicular Carcinoma

Ovarian Choriocarcinoma

Heart Failure

Image of trial facility.

High Intensity Interval Training

for Congenital Heart Disease

Congenital heart disease (CHD), the most common birth defect, is present in nearly 1% of the population. CHD patients are associated with intense resource utilization and premature death in adulthood. The risk of premature death is linked with reduced exercise capacity, a finding consistently noted in youth with CHD. Reduced exercise capacity in this population has also been associated with reduce physical activity and health-related quality of life. Cardiac rehabilitation (CR) in adults with acquired heart disease is an established secondary prevention strategy that improves exercise capacity. The investigators propose a prospective clinical trial of a home-based high intensity interval training (HIIT) program using a novel telemedicine-equipped video game-linked cycle ergometer (MedBIKEâ„¢) for 10 to 18 year olds with repaired moderate-complex CHD. The pilot study with the MedBIKE has shown promising results. The investigators now seek to study the efficacy of this program in a broader CHD population.

Recruiting

1 award

N/A

2 criteria

Image of trial facility.

High-Intensity Interval Training

for Pediatric Heart Transplant Recipients

Heart transplantation is the long-term treatment for children and adults with advanced heart failure. Post-transplant outcomes have improved over time, such that 50% of pediatric heart transplant recipients (HTR) remain alive with a need for re-transplantation 17-years following the initial transplant. With improved short- and medium-term outcomes, focus has shifted towards optimizing long-term survival and reducing transplant-associated morbidities. This includes strategies aimed at optimizing cardiorespiratory fitness and physical activity levels. Pediatric and adult HTRs have reduced exercise capacity compared with the general population. Previous groups have shown gradual improvements in heart rate response to exercise and exercise capacity in pediatric HTRs. However, after an initial improvement, exercise capacity appears to plateau, or even decline in pediatric HTRs, and remains sub-optimal compared with the general population. Most exercise interventions in HTRs to date have focused on moderate-intensity continuous exercise (MICE), with some resistance components incorporated. More recently, high-intensity interval training (HIIT), consisting of short, intense bursts of exercise with rest periods, has been explored in the adult HTR population, with findings to date suggesting that it may yield greater improvements in cardiorespiratory fitness compared with MICE. Exercise interventions, particularly HIIT interventions, have consistently shown clinically important improvements in exercise capacity in adult HTRs that are linked with improved long-term post-transplant outcomes and well-being. Unfortunately, trials of exercise interventions in pediatric HTRs remain lacking. This study team is proposing an assessment of the feasibility of a home-based HIIT exercise program using a novel telemedicine-enable video game linked customizable cycle ergometer (MedBIKEâ„¢).

Recruiting

1 award

N/A

Image of trial facility.

Exercise MRI

for Congenital Heart Disease

There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.

Recruiting

1 award

N/A

3 criteria

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